Determination of chromium and selected elements in multimineral and multivitamin preparations and in pharmaceutical raw material

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 32; no. 3; pp. 425 - 432
• Main Authors: Sołtyk, Krystyna, Łozak, Anna, Ostapczuk, Peter, Fijałek, Zbigniew
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 14.07.2003; Elsevier Science
• Subjects: Analytical, structural and metabolic biochemistry; Anthraquinones - analysis; Biological and medical sciences; Calcium - analysis; Capsules - analysis; Chlorophyta - chemistry; Chromium - analysis; Determination of chromium; Dietary Supplements - analysis; ET AAS; Fundamental and applied biological sciences. Psychology; ICP-MS; Indicators and Reagents; Inorganic compounds; Iron - analysis; Other biological molecules; Pharmaceutical preparations; Spectral interferences; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Atomic; Tablets - analysis; Trace elements; Vitamins - analysis; Determination of chromium; Pharmaceutical preparations; Trace elements; ICP-MS; Spectral interferences; ET AAS; Inductive coupling plasma spectrometry; Inorganic element; Analysis method; Multivitamin; Chromium; Dosage form; Mass spectrometry; Quantitative analysis; Atomic absorption spectrometry
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/S0731-7085(03)00240-1

The content of elements in pharmaceutical preparations is one of the indispensable factors of the evaluation of their quality. In the present work, the following macro- and microelements Ca, Cr, Cu, Fe, Mg, Mn, Mo, P, Se and Zn were determined in multimineral and multivitamin preparations and in pharmaceutical raw material. Inductively coupled plasma mass spectrometry (ICP-MS) and electrothermal atomic absorption spectrometry (ET AAS) were used throughout the study. The examined samples were dissolved in a high-pressure microwave system using concentrated nitric acid. The effect of the carbon residue in the digest solution on the determination result was eliminated by introducing an equation correcting the ArC + interference with 52Cr.