Gender differences in the effect of type 2 diabetes on serum lipids, pre-heparin plasma lipoprotein lipase mass and other metabolic parameters in Japanese population

• Published in: Diabetes research and clinical practice Vol. 62; no. 1; pp. 39 - 45
• Main Authors: Kobayashi, Junji, Maruyama, Tokiko, Watanabe, Hideaki, Kudoh, Akito, Tateishi, Sumiko, Sasaki, Takeyoshi, Murano, Shunichi, Watanabe, Mitsuyo
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.10.2003; Elsevier Science
• Subjects: Biological and medical sciences; Blood Pressure; Body Mass Index; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glycated Hemoglobin A - metabolism; Heparin; Humans; Intra-abdominal fat; Japan; Leptin; Lipids - blood; Lipoprotein Lipase - blood; Lipoprotein lipase mass; Male; Medical sciences; Middle Aged; Remnant-like particle; Sex Characteristics; Triglycerides - blood; Asia; Japan; Intra-abdominal fat; Remnant-like particle; Lipoprotein lipase mass; Diabetes mellitus; Leptin; Endocrinopathy; Type 2 diabetes; Adipose tissue; Sex; Lipids; Esterases; Anticoagulant; Lipoprotein lipase; Blood plasma; Particle; Serum; Human; Enzyme; Metabolism; Carboxylic ester hydrolases; Abdomen; Mass; Glycosaminoglycan; Hydrolases; Heparin
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/S0168-8227(03)00160-8

Design: Cross-sectional study of fasting serum lipid and lipoprotein levels, pre-heparin lipoprotein lipase (LPL) mass, several other metabolic parameters, and intra-abdominal fat areas in 26 Japanese poorly controlled type 2 diabetic men and 23 women when matched for age, body mass index (BMI), and HbA 1c between genders. Subjects: Study subjects were Japanese type 2 diabetic patients who were admitted to our hospital between Jun 2001 and Aug 2002 because of their poorly controlled diabetes. A total of 49 subjects [40–79 years of age, average age 61.5±8.7; mean BMI 23.2±3.7 kg/m 2] with fasting plasma glucose (PG) and HbA 1c levels being 251±76.5 mg/dl and 10.8±2.2%, respectively, were involved in this study. Methods: Pre-heparin LPL mass was determined by enzyme linked immunosorbent assay. Remnant like particle cholesterol (RLP-C) level was measured using an immunoaffinity mixed gel containing anti-apolipoprotein (apo) A-I and anti-apo B monoclonal antibodies. Serum leptin level was determined by radioimmunoassay. Intra-abdominal fat area was determined by computerized tomography analysis at the umbilical level. Results: The men group showed a higher serum triglycerides (TG) and RLP-C levels, and lower high density lipoprotein–cholesterol levels and pre-heparin plasma LPL mass than did women. Serum leptin level was higher in women than in men counterparts. The intra-abdominal subcutaneous fat areas were significantly larger in women than in men counterparts, whereas the visceral fat areas did not differ. Conclusion: In Japanese population, poorly controlled type 2 diabetic men had more unfavorable lipid profile than did women counterparts, which may be associated with decreased lipolysis of plasma TG-rich lipoproteins by LPL.