Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi

• Published in: European journal of medicinal chemistry Vol. 50; pp. 230 - 235
• Main Authors: Sashidhara, Koneni V., Singh, Suriya P., Misra, Sweta, Gupta, Jyoti, Misra-Bhattacharya, Shailja
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Masson SAS 01.04.2012; Elsevier
• Subjects: Animals; Anthelmintics - isolation & purification; Anthelmintics - pharmacology; Antifilarial; Bauhinia - chemistry; Bauhinia racemosa; Biological and medical sciences; Brugia malayi; Brugia malayi - drug effects; Diethylcarbamazine - therapeutic use; Elephantiasis, Filarial - drug therapy; Elephantiasis, Filarial - parasitology; Filaricides - isolation & purification; Filaricides - pharmacology; Galactolipids; Galactolipids - isolation & purification; Galactolipids - pharmacology; General pharmacology; Humans; Ivermectin - therapeutic use; Jird; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Plant Leaves - chemistry; Asia; India; Jird; Bauhinia racemosa; Antifilarial; Galactolipids; Brugia malayi; Intraperitoneal administration; Lipids; Medicinal plant; Dicotyledones; Angiospermae; Subcutaneous administration; Nematoda; Lymphatic filariasis; Pharmacognosy; Rodentia; Parasitosis; Helminthiasis; In vitro; Biological activity; Glycolipid; Lymphatic vessel disease; Infection; In vivo; Vertebrata; Chemotherapy; Experimental disease; Mammalia; Treatment; Leguminosae; Animal; Nematode disease; Plant origin; Helmintha; Parasiticide; Isolation; Nemathelminthia; Spermatophyta; Invertebrata; Gerbil; Structural analysis
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2012.01.057

Bioassay guided fractionation of ethanolic extract of the leaves of Bauhinia racemosa led to the isolation of galactolipid and catechin class of the compounds (1–7) from the most active n-butanol fraction (F4). Among the active galactolipids, 1 emerged as the lead molecule which was active on both forms of lymphatic filarial parasite, Brugia malayi. It was found to be better than the standard drug ivermectin and diethylcarbamazine (DEC) in terms of dose and efficacy. Galactolipids isolated from Bauhinia racemosa showed antifilarial activity against B. malayi. Galactolipid 1 was found to be the lead molecule showing better results than the standard drugs [Display omitted] ► Galactolipids were identified as a new class of antifilarial agents. ► Galactolipid 1 was the lead molecule, active on both life stages of B. malayi. ► It showed 58.3±8.33% adulticidal activity at a dose of 50mg/kg, i.p. ► It was better than the standard drug DEC in terms of dose and efficacy.