Significance of Intercellular adhesion molecule-1 Lys496Glu gene polimorphism on plasma redox status regulation in laryngeal carcinoma

• Published in: Journal of cancer research and therapeutics Vol. 19; no. 7; pp. 1781 - 1787
• Main Authors: Yanar, Karolin, Atayik, Mehmet Can, Horozoğlu, Cem, Demirkol, Şeyda, Simsek, Bahadir, Verim, Aysegul, Küçükhüseyin, Özlem, Aydın, Seval, Yaylım, İlhan, Çakatay, Ufuk
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.10.2023; Medknow Publications & Media Pvt. Ltd
• Subjects: Alleles; Blood proteins; Cancer; Carcinoma; Cell adhesion molecules; Development and progression; Ethylenediaminetetraacetic acid; Genes; Genetic aspects; Genetic polymorphisms; Health aspects; Humans; Intercellular Adhesion Molecule-1 - genetics; Laryngeal cancer; Laryngeal Neoplasms - genetics; Medical research; Medicine, Experimental; Oxidation-Reduction; Oxidation-reduction reaction; Physiological aspects; Plasma; Polymorphism; Single nucleotide polymorphisms; Turkey
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/jcrt.jcrt_1081_21

Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The present research is conducted to investigate whether specific gene polymorphism of ICAM-1 K469E (rs5498) and plasma redox status could be associated with laryngeal cancer (LC) development. Since there is no clear evidence which investigates the relationship between ICAM-1 polymorphism and ROS-mediated plasma protein oxidation in LC, our study is the first significant contribution for investigating the relationship. The study covered patients with primary LC and their age-matched healthy control subjects. Evaluation of ICAM-1 K469E (rs5498) gene polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Plasma redox status was assessed with spectrophotometric methods. In the current paper, we found that LC patients with GG genotype had a decreasing trend for the plasma oxidative damage biomarker levels when compared with all allele genotypes (AA and AG). We concluded that G allele of the ICAM-1 K469E gene plays a significant role in the optimal regulation of plasma redox homeostasis in patients with LC.