Volumetric assessment of myocardial viability in rats using 3D double contrast enhanced T1 and T2-weighted MRI

• Published in: Magma (New York, N.Y.) Vol. 18; no. 6; pp. 302 - 308
• Main Authors: Chapon, C, Franconi, F, Lemaire, L, Marescaux, L, Legras, P, Denizot, B, Le Jeune, J-J
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.12.2005; Springer Verlag
• Subjects: Analysis of Variance; Animals; Bioengineering; Contrast Media; Heterocyclic Compounds; Imaging; Imaging, Three-Dimensional - methods; Injection; Iron oxides; Life Sciences; Magnetic Resonance Imaging - methods; Medication; Myocardial infarction; Myocardial Infarction - pathology; Myocardial Infarction - therapy; Nanotechnology; Organometallic Compounds; Particle Size; Pharmaceutical sciences; Rats
• ISSN: 0968-5243; 1352-8661
• DOI: 10.1007/s10334-005-0016-9

Volumetric evaluation of the myocardial viability post-infarction in rats using 3D in vivo MR imaging at 7 T using injection of an extracellular paramagnetic contrast agent and intravascular superparamagnetic iron oxide nanoparticles in the same imaging session. Five hours after induction of permanent myocardial infarction in rats (n=6), 3D in vivo T1- and T2-weighted MR Imaging was performed prior to and after Gd-DOTA injection (0.2 mmol/kg) and prior to and after nanoparticle injection (5 mg Fe/kg) to assess infarct size and myocardial viability. 3D MR Imaging using a successive contrast agent injection showed a difference of infarct size after Gd-DOTA injection on T1-weighted images compared to the one measured on T2-weighted images after Gd-DOTA and nanoparticle injection. The use of 3D T1- and T2-weighted MR Imaging using a double contrast agents protocol made possible the accurate characterization of myocardial infarction volume and allowed the detection of myocardial viability post-infarction in rats.