Dysautonomia Following Tetanus, Diphtheria, and Pertussis Vaccine (Tdap): The First Case of Extreme Cachexia Caused by Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) in a Human

Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA; Shoenfeld's syndrome) comprehends a group of autoimmune conditions that flourish in genetically predisposed individuals, following an external stimulus by the so-called adjuvants. Many adjuvants were described, such as vaccines, alumi...

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Published inMedicina (Kaunas, Lithuania) Vol. 57; no. 12; p. 1333
Main Authors Hen, Or, David, Paula, Shoenfeld, Yehuda
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.12.2021
MDPI
Subjects
Adjuvants
Adolescent
Aluminum
Antibodies
Antibodies, Bacterial
Antigens
autoimmune/inflammatory syndrome induced by adjuvants
autoimmunity
Breast implants
Cachexia
Case Report
Chronic fatigue syndrome
Cytokines
Diphtheria
Female
Headaches
Humans
Laboratories
molecular mimicry
Orthopedics
Patients
Peptides
Pertussis Vaccine
Primary Dysautonomias - complications
TDaP
Tetanus
vaccine
Vaccines
Whooping cough
molecular mimicry
vaccine
autoimmunity
autoimmune/inflammatory syndrome induced by adjuvants
cachexia
TDaP
aluminum
autoantibodies
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Summary:Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA; Shoenfeld's syndrome) comprehends a group of autoimmune conditions that flourish in genetically predisposed individuals, following an external stimulus by the so-called adjuvants. Many adjuvants were described, such as vaccines, aluminum and other metals, silicone, tattoos, among others. Those conditions entail defined diseases, such as sarcoidosis and Sjogren's syndrome, and generalized complex symptoms, for example, fatigue, sleep disturbance, orthostatic intolerance, and other dysautonomic manifestations. Those complaints were previously associated with autoantibodies against nervous system autonomic receptors, especially antibeta 1 adrenergic receptor antibodies, suggesting the autoimmune component of the condition. Here we report on a case of an 18-year-old woman who presented with extreme cachexia due to severe dysautonomia caused by the ASIA syndrome induced by the tetanus, diphtheria, and pertussis vaccine (Tdap).
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina57121333