Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects

• Published in: Aging (Albany, NY.) Vol. 12; no. 12; pp. 12376 - 12392
• Main Authors: Honkonen, Milja, Vääräniemi, Kati, Saijonmaa, Outi, Nyman, Anna, Tikkakoski, Antti J., Koskela, Jenni, Lehtimäki, Terho, Kähönen, Mika, Mustonen, Jukka, Fyhrquist, Frej, Pörsti, Ilkka
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 23.06.2020
• Subjects: Adult; Aged; Aging - genetics; Blood Pressure - genetics; Cardiography, Impedance; Female; Humans; Hypertension - blood; Hypertension - genetics; Leukocytes - metabolism; Male; Middle Aged; Prospective Studies; Pulse Wave Analysis; Research Paper; Telomere Homeostasis - physiology; Vascular Resistance - genetics; Young Adult; aging; hemodynamics; circulatory system; telomeres
• ISSN: 1945-4589; 1945-4589
• DOI: 10.18632/aging.103459

Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP and mean LTL were determined using Southern blotting, and supine hemodynamics recorded using continuous tonometric pulse wave analysis and whole-body impedance cardiography. The analyses were adjusted for age, body mass index (BMI), alcohol use, smoking, plasma chemistry, and estimated glomerular filtration rate (eGFR). In univariate analyses, mean LTL and STP both correlated with age, BMI, eGFR, aortic blood pressure, augmentation index, and pulse wave velocity (p<0.05 for all). Mean LTL also correlated with systemic vascular resistance (p<0.05). In linear regression analyses of all hemodynamic variables, mean LTL was only an independent explanatory factor for augmentation index (Beta -0.006, p=0.032), while STP was not an explanatory factor for any of the hemodynamic variables, in contrast to age, BMI and several cardiovascular risk factors. To conclude, augmentation index was predominantly related with chronological aging, but also with mean LTL, suggesting that this variable of central wave reflection is a modest marker of vascular biological aging.