Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains

• Published in: Journal of natural medicines Vol. 63; no. 1; pp. 41 - 45
• Main Authors: Rahman, A. K. M. Shahidur, Chowdhury, A. K. Azad, Ali, Husne-Ara, Raihan, Sheikh Z., Ali, Mohammad S., Nahar, Lutfun, Sarker, Satyajit D.
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.01.2009
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Biomedical and Life Sciences; Biomedicine; Chromatography, Thin Layer; Complementary & Alternative Medicine; Drug Resistance, Multiple, Bacterial - drug effects; Limonins - chemistry; Limonins - isolation & purification; Limonins - pharmacology; Medicinal Chemistry; Meliaceae - chemistry; Microbial Sensitivity Tests; Molecular Structure; Original Paper; Pharmacology/Toxicology; Pharmacy; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Sciences; Multiple-drug-resistance (MDR); Antibacterial; Limonoid; Meliaceae
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-008-0287-3

Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide ( 1 ) and 2-hydroxy-3- O -tigloylswietenolide ( 2 ). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eight multiple-drug-resistant bacterial strains (clinical isolates) by the conventional disc diffusion method. While both compounds were active against all test organisms, compound 2 displayed overall more potent activity than compound 1 .