G-protein-coupled receptors and cancer

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously,...

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Bibliographic Details
Published in	Nature reviews. Cancer Vol. 7; no. 2; pp. 79 - 94
Main Authors	Gutkind, J. Silvio, Dorsam, Robert T
Format	Journal Article
Language	English
Published	England Nature Publishing Group 01.02.2007
Subjects	Cell receptors Cellular signal transduction DNA Damage Health aspects Humans Inflammation - physiopathology Neoplasm Metastasis Neoplasms - blood supply Neoplasms - pathology Neoplasms - physiopathology Neovascularization, Pathologic Physiological aspects Protein Conformation Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - physiology Ultraviolet Rays United States
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Abstract	G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply, invade their surrounding tissues and disseminate to other organs. This Review will address our current understanding of the many roles of GPCRs and their signalling circuitry in tumour progression and metastasis. We will also discuss how interfering with GPCRs might provide unique opportunities for cancer prevention and treatment.
AbstractList	G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply, invade their surrounding tissues and disseminate to other organs. This Review will address our current understanding of the many roles of GPCRs and their signalling circuitry in tumour progression and metastasis. We will also discuss how interfering with GPCRs might provide unique opportunities for cancer prevention and treatment.
Audience	Academic
Author	Dorsam, Robert T Gutkind, J. Silvio
Author_xml	– sequence: 1 givenname: J. Silvio surname: Gutkind fullname: Gutkind, J. Silvio organization: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health – sequence: 2 givenname: Robert T surname: Dorsam fullname: Dorsam, Robert T organization: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17251915$$D View this record in MEDLINE/PubMed
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Snippet	G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in...
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SubjectTerms	Cell receptors Cellular signal transduction DNA Damage Health aspects Humans Inflammation - physiopathology Neoplasm Metastasis Neoplasms - blood supply Neoplasms - pathology Neoplasms - physiopathology Neovascularization, Pathologic Physiological aspects Protein Conformation Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - physiology Ultraviolet Rays
Title	G-protein-coupled receptors and cancer
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