G-protein-coupled receptors and cancer

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously,...

Full description

Saved in:
Bibliographic Details
Published inNature reviews. Cancer Vol. 7; no. 2; pp. 79 - 94
Main Authors Gutkind, J. Silvio, Dorsam, Robert T
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.2007
Subjects
Cell receptors
Cellular signal transduction
DNA Damage
Health aspects
Humans
Inflammation - physiopathology
Neoplasm Metastasis
Neoplasms - blood supply
Neoplasms - pathology
Neoplasms - physiopathology
Neovascularization, Pathologic
Physiological aspects
Protein Conformation
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - physiology
Ultraviolet Rays
United States
Online AccessGet full text

Cover

More Information
Summary:G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply, invade their surrounding tissues and disseminate to other organs. This Review will address our current understanding of the many roles of GPCRs and their signalling circuitry in tumour progression and metastasis. We will also discuss how interfering with GPCRs might provide unique opportunities for cancer prevention and treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Review-2
ISSN:1474-175X
1474-1768
DOI:10.1038/nrc2069