Anti-metastatic effects of aqueous extract of Helixanthera parasitica

• Published in: Journal of ethnopharmacology Vol. 86; no. 2; pp. 253 - 256
• Main Authors: Lirdprapamongkol, Kriengsak, Mahidol, Chulabhorn, Thongnest, Sanit, Prawat, Hunsa, Ruchirawat, Somsak, Srisomsap, Chantragan, Surarit, Rudee, Punyarit, Phaibul, Svasti, Jisnuson
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.2003; Elsevier
• Subjects: Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antioxidant; Biological and medical sciences; Carcinoma, Hepatocellular - drug therapy; General pharmacology; Humans; Invasion; Liver cancer; Liver Neoplasms - drug therapy; Medical sciences; Medicinal plants; Metastasis; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Plants, Medicinal; Thai herbs; Thailand; Tumor Cells, Cultured - drug effects; Thailand; Asia; Medicinal plants; Thai herbs; Liver cancer; Metastasis; Antioxidant; Invasion; Antineoplastic agent; Human; Extract; Malignant tumor; Loranthaceae; In vitro; Biological activity; Medicinal plant; Dicotyledones; Angiospermae; Established cell line; Plant origin; Spermatophyta; Tumor cell
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(03)00072-2

Metastasis, the spread of cancer in body, is a major cause of death. We have screened anti-metastatic activity of aqueous and dichloromethane extracts of several not previously studied Thai herbs, using an in vitro invasion test. This involves the in vitro invasion of HCC-S102, a hepatocellular carcinoma cell line derived from a Thai patient, through a reconstituted-basement membrane (Matrigel). The aqueous extract of a plant ( Helixanthera parasitica) revealed a significant inhibitory effect on the cancer cell invasion, and showed antioxidant activity. The aqueous extract was partially purified by silica gel column chromatography, and the highest anti-metastatic activity fraction showed 83% inhibition of invasion with low cytotoxic effect. However, anti-metastatic activity was not associated with the antioxidant activity of the aqueous extract.