Artificial viruses: a nanotechnological approach to gene delivery

Nanotechnology is a rapidly expanding multidisciplinary field in which highly sophisticated nanoscale devices are constructed from atoms, molecules or (macro)molecular assemblies. In the field of gene medicine, systems for delivering nucleic acids are being developed that incorporate virus-like func...

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Bibliographic Details
Published inNature reviews. Drug discovery Vol. 5; no. 2; pp. 115 - 121
Main Authors Mastrobattista, Enrico, van der Aa, Marieke A. E. M, Hennink, Wim E, Crommelin, Daan J. A
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.2006
Subjects
Animals
DNA - administration & dosage
DNA - genetics
Genetic Therapy - trends
Genetic Vectors
Humans
Nanotechnology - trends
Virus Assembly - physiology
Viruses - genetics
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Summary:Nanotechnology is a rapidly expanding multidisciplinary field in which highly sophisticated nanoscale devices are constructed from atoms, molecules or (macro)molecular assemblies. In the field of gene medicine, systems for delivering nucleic acids are being developed that incorporate virus-like functions in a single nanoparticle. Although their development is still in its infancy, it is expected that such artificial viruses will have a great impact on the advancements of gene therapeutics.
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ISSN:1474-1776
1474-1784
DOI:10.1038/nrd1960