Inflammatory myofibroblastic tumor from the greater omentum in children: A rare case report

• Published in: Journal of cancer research and therapeutics Vol. 18; no. 7; pp. 2066 - 2069
• Main Authors: Song, Honghao, Zhang, Huiyu, Zhang, Yongfei, Wang, Xiaoqing, Liu, Wei
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.12.2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Subjects: Anaplastic Lymphoma Kinase; Cancer; Care and treatment; Case reports; Causes of; Child, Preschool; Diagnosis; Female; Fever; Fibrosarcoma; Granuloma, Plasma Cell - diagnostic imaging; Granuloma, Plasma Cell - surgery; Humans; Hyperthermia; Immunohistochemistry; Omentum - pathology; Omentum - surgery; Relapse; Stomach - pathology; Tumors; China; IMT; greater omentum; Children; Inflammatory myofibroblastic tumor
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/jcrt.jcrt_1089_22

Inflammatory myofibroblastic tumor (IMT) prevalence is less than one in a million. Anaplastic lymphoma kinase (ALK)-positive IMT in the greater omentum and with a diameter greater than 8 cm is extremely rare. Here, we present a case and provide a brief literature review. A 4-year-old female was referred to our hospital with a 1-month history of intermittent fever. Computed tomography revealed a 6.4 × 5.5 × 6.5-cm lesion between the spleen and stomach. During the operation, we confirmed that the mass originated in the greater omentum and completely resected the mass, achieving a negative margin. The maximum cross-sectional area of the tumor after surgery was 8.3 × 7.5 cm. The immunohistochemistry result of this IMT was ALK (+), S100 (−), Ki-67+ (20%), Desmin (+), CD21 (−), CD35 (+), Vim (+), and SMA (+). The final pathology was IMT. No local recurrence or metastasis has been observed in the 8 months of follow-up.