A NEW ANTITUMOR SUBSTANCE, BE-18591, PRODUCED BY A STREPTOMYCETE I. FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

• Published in: Journal of antibiotics Vol. 46; no. 12; pp. 1799 - 1803
• Main Authors: KOJIRI, KATSUHISA, NAKAJIMA, SHIGERU, SUZUKI, HAJIME, OKURA, AKIRA, SUDA, HIROYUKI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1993; Japan Antibiotics Research Association
• Subjects: Animals; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, Antineoplastic - metabolism; Antibiotics, Antineoplastic - pharmacology; Biological and medical sciences; Cell Division - drug effects; Chemical Phenomena; Chemistry, Physical; Fermentation; General pharmacology; Leukemia P388 - drug therapy; Leukemia P388 - pathology; Magnetic Resonance Spectroscopy; Medical sciences; Mice; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Pyrroles - isolation & purification; Pyrroles - metabolism; Pyrroles - pharmacology; streptomyces; Streptomyces - chemistry; Streptomyces - metabolism; Actinomycetales; Antineoplastic agent; Streptomycetaceae; Microbial origin; Streptomyces; Bacteria; Cytotoxicity; Isolation; Actinomycetes; Biological activity; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.46.1799

New antitumor substance, designated BE-18591, was isolated from the culture broth of a streptomycete, strain BA18591. The active principle was extracted from mycelium by methanol and purified by silica gel chromatography. BE-18591 inhibited the growth of MKN-45 human stomach cancer cell line as well as P388 cell line. In in vivo experiments, BE-18591 inhibited the growth of Ehrlich ascites tumor.BE-18591 showed antimicrobial activity against Gram-positive and some Gram-negative bacteria.