ARLTS1 variants and melanoma risk

Variants in the tumor suppressor gene ARLTS1 (ADP‐ribosylation factor‐like tumor‐suppressor gene 1) have been shown to influence familial cancer risk. Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high‐risk familial breast cancer, respectively. We studied the im...

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Published inINTERNATIONAL JOURNAL OF CANCER Vol. 119; no. 7; pp. 1736 - 1737
Main Authors Frank, Bernd, Meyer, Peter, Boettger, Melanie Barbara, Hemminki, Kari, Stapelmann, Henrike, Gast, Andreas, Schmitt, Christina, Kumar, Rajiv, Sergi, Consolato, Burwinkel, Barbara
Format Journal Article Publication
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2006
Wiley-Liss
Subjects
Adolescent
ADP-Ribosylation Factors - genetics
Adult
Aged
Aged, 80 and over
Biological and medical sciences
cancer risk
Child
Dermatology
Female
Genetic Variation - genetics
Genotype
Humans
Male
Medical sciences
melanoma
Melanoma - diagnosis
Melanoma - genetics
Middle Aged
multiple melanomas
polymorphism
Risk Factors
tumor suppressor gene
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
Europe
Germany
Human
Skin disease
Genetic variability
Genotype
melanoma
Malignant tumor
Epidemiology
Cancerology
Risk factor
Malignant melanoma
cancer risk
Genetics
multiple melanomas
ADP ribosylation factor like tumor suppressor gene 1
Public health
Tumor suppressor gene
Polymorphism
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Summary:Variants in the tumor suppressor gene ARLTS1 (ADP‐ribosylation factor‐like tumor‐suppressor gene 1) have been shown to influence familial cancer risk. Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high‐risk familial breast cancer, respectively. We studied the impact of these gene variants on melanoma risk, investigating 351 melanoma patients and 804 control subjects. While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37–1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05–1.95, p = 0.02). An additional risk enhancement, though statistically non‐significant, was observed in individuals with multiple melanomas (OR = 2.33, 95% CI = 0.87–6.26, p = 0.08). © 2006 Wiley‐Liss, Inc.
Bibliography:Bernd Frank and Peter Meyer contributed equally to this work.
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ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.22008