Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis

We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal seco...

Full description

Saved in:
Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 40; no. 1; p. e43
Main Authors LaCourse, Sylvia M, Leon, Daniel, Panpradist, Nuttada, Richardson, Barbra A, Maleche-Obimbo, Elizabeth, Mecha, Jerphason, Matemo, Daniel, Escudero, Jaclyn N, Kinuthia, John, Lutz, Barry, John-Stewart, Grace
Format Journal Article
LanguageEnglish
Published United States 01.01.2021
Subjects
Antitubercular Agents - therapeutic use
Biomarkers - urine
Cohort Studies
Female
HIV Infections
Humans
Infant
Isoniazid - therapeutic use
Isoniazid - urine
Kenya
Male
Medication Adherence
Randomized Controlled Trials as Topic
Tuberculosis - drug therapy
Tuberculosis - prevention & control
Kenya
Online AccessGet more information

Cover

More Information
Summary:We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past 3 days, suggesting caregiver education and self-medication use influenced infant adherence.
ISSN:1532-0987
DOI:10.1097/INF.0000000000002936