Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine‐rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese popula...

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Published inAnnals of neurology Vol. 64; no. 1; pp. 88 - 92
Main Authors Ross, Owen A., Wu, Yih-Ru, Lee, Mei-Ching, Funayama, Manabu, Chen, Meng-Ling, Soto, Alexandra I., Mata, Ignacio F., Lee-Chen, Guey-Jen, Chen, Chiung Mei, Tang, Michelle, Zhao, Yi, Hattori, Nobutaka, Farrer, Matthew J., Tan, Eng-King, Wu, Ruey-Meei
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2008
Willey-Liss
Subjects
Asian Continental Ancestry Group - ethnology
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
DNA Mutational Analysis
Female
Founder Effect
Gene Frequency
Genetic Markers - genetics
Genetic Predisposition to Disease - genetics
Genetic Testing
Genotype
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male
Medical sciences
Middle Aged
Mutation - genetics
Neurology
Parkinson Disease - ethnology
Parkinson Disease - genetics
Parkinson Disease - metabolism
Polymorphism, Genetic - genetics
Protein-Serine-Threonine Kinases - genetics
Singapore - epidemiology
Taiwan - epidemiology
Nervous system diseases
Central nervous system disease
Risk factor
Parkinson disease
Degenerative disease
Cerebral disorder
Extrapyramidal syndrome
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Summary:Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine‐rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20–2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008
Bibliography:National Medical Research Council - No. CSI/001/2005
ark:/67375/WNG-J2P5CG2Z-G
Biomedical Research Council - No. 04/1/27/19/371
American Parkinson's Disease Association
Taiwan National Science Council - No. NSC96-2628-B-002-103-MY2
ArticleID:ANA21405
Michael J. Fox award (RRIA)
Morris K. Udall Center for Excellence in Parkinson's Disease Research at Mayo Clinic - No. P50 NS40256
SingHealth, Singapore - No. 1E012/2005
istex:3EFF2977AB36F3C9551CF8C69351F2522413E1B3
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.21405