WF11899A, B AND C, NOVEL ANTIFUNGAL LIPOPEPTIDES I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

WF 11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899. These compounds belong to the echinocandin type of lipopeptides. Of these compounds, WF11899 A showed good solubility in water. These three antibiotics possess potent in v...

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Published inJournal of antibiotics Vol. 47; no. 10; pp. 1084 - 1091
Main Authors IWAMOTO, TOSHIRO, FUJIE, AKIHIKO, SAKAMOTO, KAZUTOSHI, TSURUMI, YASUHISA, SHIGEMATSU, NOBUHARU, YAMASHITA, MICHIO, HASHIMOTO, SEIJI, OKUHARA, MASAKUNI, KOHSAKA, MASANOBU
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1994
Japan Antibiotics Research Association
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Biological and medical sciences
Candida - drug effects
Chemical Phenomena
Chemistry, Physical
Female
Fermentation
Lipopeptides
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Mice, Inbred ICR
Mitosporic Fungi - classification
Mitosporic Fungi - metabolism
Mitosporic Fungi - ultrastructure
Peptides, Cyclic - biosynthesis
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Pharmacology. Drug treatments
Solubility
Antibiotic
Antifungal agent
Microbial origin
Taxonomy
Isolation
Fermentation
Physicochemical properties
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Summary:WF 11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899. These compounds belong to the echinocandin type of lipopeptides. Of these compounds, WF11899 A showed good solubility in water. These three antibiotics possess potent in vitro antifungal activities against Candida spp.
Bibliography:ObjectType-Article-2
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.47.1084