Serum fetoprotein and malignancy in children

This study was undertaken to determine the incidence of alpha fetoprotein in the sera of 107 children with various malignancies. Seventy‐five of the children had demonstrable tumors while no disease appeared to be present in 32 patients. Serum alpha fetoprotein was detected in seven patients using a...

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Published inCancer Vol. 30; no. 1; pp. 80 - 83
Main Authors Finklestein, Jerry Z., Higgins, Gussie R., Faust, Judy, Karon, Myron
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.07.1972
Subjects
Animals
Child, Preschool
Cross Reactions
Female
Fetal Proteins - analysis
Haplorhini - immunology
Humans
Immune Sera - analysis
Infant
Lymphoma, Non-Hodgkin - blood
Male
Neoplasms - blood
Neuroblastoma - blood
Rhabdomyosarcoma - blood
Teratoma - blood
Testicular Neoplasms - blood
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Summary:This study was undertaken to determine the incidence of alpha fetoprotein in the sera of 107 children with various malignancies. Seventy‐five of the children had demonstrable tumors while no disease appeared to be present in 32 patients. Serum alpha fetoprotein was detected in seven patients using antiserum to monkey alpha fetoprotein (three with rhabdomyosarcomas, 1 each with neuroblastoma, lymphosarcoma, teratoma, and orchioblastoma). Using antiserum to human alpha fetoprotein, only two of these sera showed reactions of identity with human alpha fetoprotein (malignant teratoma and orchioblastoma). The disappearance of alpha fetoprotein from the serum of one patient correlated with complete surgical removal of the tumor. The protein disappeared from the sera of two children with inoperable tumors following intensive chemotherapy and radiation therapy. The determination of alpha fetoprotein may provide a valuable parameter for the evaluation of the activity of disease in children with certain tumors.
Bibliography:Assistant Professor of Pediatrics, University of California, Los Angeles
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197207)30:1<80::AID-CNCR2820300113>3.0.CO;2-G