Placental autotaxin expression is diminished in women with pre-eclampsia
Aim Lysophosphatidic acid (LPA) is a member of a new class of lipid mediators and exerts varied physiological and pathological functions. The secreted protein, autotaxin (ATX), is a key enzymatic determinant of local LPA production. The primary aim of this study was to investigate the potential invo...
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Published in | The journal of obstetrics and gynaecology research Vol. 41; no. 9; pp. 1406 - 1411 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Australia
Blackwell Publishing Ltd
01.09.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Aim
Lysophosphatidic acid (LPA) is a member of a new class of lipid mediators and exerts varied physiological and pathological functions. The secreted protein, autotaxin (ATX), is a key enzymatic determinant of local LPA production. The primary aim of this study was to investigate the potential involvement of the placental ATX–LPA system in pre‐eclampsia (PE).
Material and Methods
We compared human placental ATX mRNA expression in pregnancies complicated by severe PE with that in healthy placentas using real‐time polymerase chain reaction. We further assessed whether these expression levels were associated with disease‐onset patterns.
Results
Placental transcription of ATX increased progressively during normal pregnancy. In the analysis for pre‐eclamptic placentas, the placental ATX expression in the early‐onset group, but not in late‐onset group, was significantly lower compared to normal controls. Multiple regression analysis revealed that occurrence of early‐onset PE, but not late‐onset PE, was a variable that was significantly associated with the placental ATX expression level.
Conclusion
These findings support our previous work showing reduced ATX antigen levels in the peripheral blood of pre‐eclamptic women. A disturbance in placental ATX production may be linked to poor placental development and systemic maternal symptoms in early‐onset PE. |
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Bibliography: | ark:/67375/WNG-BJB314DD-F istex:7DA6DCD5C7FEFAF7EB5DFE69AAA71394FC9FD0FB ArticleID:JOG12742 JSPS KAKENHI - No. 23592394, 22890045 and 25861476 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1341-8076 1447-0756 |
DOI: | 10.1111/jog.12742 |