Intravital multi‐photon microscopy reveals several levels of heterogeneity in endocytic uptake by mouse renal proximal tubules

Understanding renal function requires one to integrate the structural complexity of kidney nephrons and the dynamic nature of their cellular processes. Multi‐photon fluorescence microscopy is a state‐of‐the‐art imaging technique for in vivo analysis of kidney tubules structure and function in real t...

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Bibliographic Details
Published inJournal of cellular and molecular medicine Vol. 12; no. 1; pp. 351 - 354
Main Authors Caplanusi, A., Parreira, K.S., Lima, W. Rezende, Marien, B., Van Der Smissen, P., De Diesbach, P., Devuyst, O., Courtoy, P.J.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.2008
John Wiley & Sons, Inc
Subjects
Animals
Cells
Endocytosis
Fluorescence microscopy
fluorescent dextrans
Fluorescent Dyes - pharmacokinetics
Images in Cellular / Molecular Medicine
kidney
Kidney Tubules, Proximal - metabolism
Kidneys
Laboratory animals
Male
Mice
Mice, Inbred C57BL
Microscopy
Microscopy, Fluorescence, Multiphoton
Nephrology
Nephrons
Neuroimaging
Proximal tubules
Renal cortex
Renal function
Rodents
Structure-function relationships
Studies
Tissue Distribution
Visual perception
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Summary:Understanding renal function requires one to integrate the structural complexity of kidney nephrons and the dynamic nature of their cellular processes. Multi‐photon fluorescence microscopy is a state‐of‐the‐art imaging technique for in vivo analysis of kidney tubules structure and function in real time. This study presents visual evidence for several levels of heterogeneity of proximal tubular endocytic uptake in the superficial renal mouse cortex and illustrates the potential of multi‐photon microscopy for providing a comprehensive and dynamic portrayal of renal function.
ISSN:1582-1838
1582-4934
DOI:10.1111/j.1582-4934.2007.00192.x