Adipocytes role in the bone marrow niche

Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) using state‐of‐the‐art techniques, including sophisticated Cre/loxP technologies, confocal micros...

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Published inCytometry. Part A Vol. 93; no. 2; pp. 167 - 171
Main Authors Guerra, Daniel A. P., Paiva, Ana E., Sena, Isadora F. G., Azevedo, Patrick O., Batista, Miguel Luiz, Mintz, Akiva, Birbrair, Alexander
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.02.2018
Subjects
Adipocytes
Adipocytes - physiology
Adipocytes - transplantation
Animals
Bone marrow
Bone Marrow - physiology
Bone Marrow Cells - physiology
Bone marrow transplantation
Bone Marrow Transplantation - trends
Chemotherapy
Clonal deletion
Confocal microscopy
Cytometry
Flow cytometry
Hematological diseases
hematopoiesis
Hematopoietic stem cells
Hematopoietic Stem Cells - physiology
Humans
In vivo methods and tests
Infiltration
Irradiation
Microscopy
Radiation
Regulators
Stem cell factor
Stem cell transplantation
Stem cells
Transplantation
hematopoiesis
hematopoietic stem cells
adipocytes
bone marrow
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Summary:Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) using state‐of‐the‐art techniques, including sophisticated Cre/loxP technologies, confocal microscopy, in vivo lineage‐tracing, flow cytometry, and bone marrow transplantation, reveal that adipocytes promote hematopoietic recovery after irradiation. This study challenges the current view of adipocytes as negative regulators of the hematopoietic stem cells niche, and reopens the discussion about adipocytes' roles in the bone marrow. Strikingly, genetic deletion of stem cell factor specifically from adipocytes leads to deficiency in hematopoietic stem cells, and reduces animal survival after myeloablation, The emerging knowledge from this research will be important for the treatment of multiple hematologic disorders. © 2017 International Society for Advancement of Cytometry
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ISSN:1552-4922
1552-4930
DOI:10.1002/cyto.a.23301