Early postnatal injections of whole vaccines compared to placebo controls: Differential behavioural outcomes in mice

• Published in: Journal of inorganic biochemistry Vol. 212; p. 111200
• Main Authors: Eidi, Housam, Yoo, Janice, Bairwa, Suresh C., Kuo, Michael, Sayre, Eric C., Tomljenovic, Lucija, Shaw, Christopher A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2020; Elsevier
• Subjects: Behavioural tests; Life Sciences; Neurobehavioural abnormalities; Neurodevelopment; Pharmaceutical sciences; Vaccine; Neurodevelopment; Neurobehavioural abnormalities; Vaccine; Behavioural tests; paediatry; vaccin; vaccine; postnatal injection; injection postnatale; pédiatrie; médicament; pharmacovigilance; human; humain; vaccination; drug
• ISSN: 0162-0134; 1873-3344
• DOI: 10.1016/j.jinorgbio.2020.111200

The present study was designed to evaluate the possible effects of the paediatric vaccination schedule in the United States on the central nervous system in a murine model. We compared the impact of treatment with the whole vaccines versus true placebo control. Seventy-six pups were divided into three groups: two vaccinated groups and unvaccinated control. The two vaccinated groups were treated between 7 and 21 post-natal days either with one or three times of the vaccine doses per body weight as used in children between newborn and eighteen months of age. The post-vaccination development, neuromotor behaviours and neurobehavioural abnormalities (NBAs) were evaluated in all mouse groups during the 67 post-natal weeks of mouse age. Mouse body weight was affected only in the vaccinated females compared to males and control. Some NBAs such as decreased sociability, increased anxiety-like behaviours, and alteration of visual-spatial learning and memory were observed in vaccinated male and female mice compared to controls. The present study also shows a slower acquisition of some neonatal reflexes in vaccinated female mice compared to vaccinated males and controls. The observed neurodevelopmental alterations did not show a linear relationship with vaccine dose, suggesting that the single dose gave a saturated response. The outcomes seemed to be sex-dependent and transient with age. A schematic depicting the neurobehavioural effects of administering paediatric vaccines to mice. Not included in this schematic are the potential impacts of vaccine dose, mouse strain and Al adjuvant type. [Display omitted] •We studied the impact of vaccines on neurodevelopment in mice.•Abnormalities in vaccinated mice were detected in some tested parameters.•Most of abnormalities detected were transient.•Differential outcomes are seen between treated male and female animals.