The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication

How distal cis -regulatory elements (e.g., enhancers) communicate with promoters remains an unresolved question of fundamental importance. Although transcription factors and cofactors are known to mediate this communication, the mechanism by which diffusible molecules relay regulatory information fr...

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Bibliographic Details
Published inGenes & development Vol. 36; no. 1-2; pp. 7 - 16
Main Authors Karr, Jonathan P., Ferrie, John J., Tjian, Robert, Darzacq, Xavier
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.01.2022
Subjects
Enhancer Elements, Genetic - genetics
Gene Expression Regulation
Promoter Regions, Genetic - genetics
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
p300
3D genome
enhancer
transcription
gene regulation
coactivator
Online AccessGet full text
ISSN0890-9369
1549-5477
1549-5477
DOI10.1101/gad.349160.121

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Summary:How distal cis -regulatory elements (e.g., enhancers) communicate with promoters remains an unresolved question of fundamental importance. Although transcription factors and cofactors are known to mediate this communication, the mechanism by which diffusible molecules relay regulatory information from one position to another along the chromosome is a biophysical puzzle—one that needs to be revisited in light of recent data that cannot easily fit into previous solutions. Here we propose a new model that diverges from the textbook enhancer–promoter looping paradigm and offer a synthesis of the literature to make a case for its plausibility, focusing on the coactivator p300.
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ISSN:0890-9369
1549-5477
1549-5477
DOI:10.1101/gad.349160.121