Quantitative analysis of endoneurial T-cells in human sural nerve biopsies

We used immunocytochemical methods on sural nerve biopsies from 42 patients with peripheral neuropathy to identify mononuclear cells, determine whether lymphocytic infiltration occurs in a variety of neuropathies, and identify the subtypes of lymphocytes. Immunostained cells were present in 76% of n...

Full description

Saved in:
Bibliographic Details
Published inJournal of neuroimmunology Vol. 26; no. 2; pp. 113 - 118
Main Authors Cornblath, David R., Griffin, Diane E., Welch, Danielle, Griffin, John W., McArthur, Justin C.
Format Journal Article
LanguageEnglish
Published London Elsevier B.V 01.02.1990
Amsterdam Elsevier
New York, NY
Subjects
Biological and medical sciences
Biopsy
CD4-Positive T-Lymphocytes
Cell Count
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Eosine Yellowish-(YS)
Hematoxylin
HIV
Human
Human immunodeficiency virus infection
Humans
Immunohistochemistry
Leukocyte Count
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropathy
Peripheral Nervous System Diseases - pathology
Spinal Nerves - pathology
Staining and Labeling
Sural Nerve - pathology
T cell
T-Lymphocytes
T-Lymphocytes, Regulatory
Human
Neuropathy
HIV
T cell
Immunohistochemistry
Nervous system diseases
Helper cell
Monoclonal antibody
Peripheral neuropathy
Cell subpopulation
Characterization
Optical microscopy
Phenotype
Biopsy
T-Lymphocyte
Suppressive cell
Sural nerve
Online AccessGet full text

Cover

More Information
Summary:We used immunocytochemical methods on sural nerve biopsies from 42 patients with peripheral neuropathy to identify mononuclear cells, determine whether lymphocytic infiltration occurs in a variety of neuropathies, and identify the subtypes of lymphocytes. Immunostained cells were present in 76% of nerve biopsies. CD3 + cells (T lymphocytes) were greatest in density (cells/mm 2). In patients whose CD4: CD8 T cell ratio was measured also in blood and cerebrospinal fluid, the CD4:CD8 T cell ratio was similar in all three compartments. These findings suggest that T lymphocytes are frequently present in nerves obtained from patients with various types of neuropathies and raise questions about factorsthat attract T lymphocytes into nerve that may be important in pathogenesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-5728
1872-8421
DOI:10.1016/0165-5728(90)90082-X