Vaccine Effectiveness of JYNNEOS against Mpox Disease in the United States

• Published in: The New England journal of medicine Vol. 388; no. 26; pp. 2434 - 2443
• Main Authors: Deputy, Nicholas P., Deckert, Joseph, Chard, Anna N., Sandberg, Neil, Moulia, Danielle L., Barkley, Eric, Dalton, Alexandra F., Sweet, Cory, Cohn, Amanda C., Little, David R., Cohen, Adam L., Sandmann, Danessa, Payne, Daniel C., Gerhart, Jacqueline L., Feldstein, Leora R.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 29.06.2023
• Subjects: Adult; Case-Control Studies; Diagnosis; Disease control; Disease prevention; Effectiveness; Electronic health records; Electronic medical records; Gender identity; Global Health; HIV; HIV Infections - epidemiology; HIV Infections - prevention & control; Homosexuality, Male; Human immunodeficiency virus; Humans; Immunization; Infections; Infectious Disease; Infectious Disease General; Male; Medical laboratories; Minority & ethnic groups; Monkeypox; Mpox (monkeypox) - epidemiology; Mpox (monkeypox) - prevention & control; Non-binary gender; Orthopoxvirus; Prophylaxis; Ratios; Regression analysis; Sexual and Gender Minorities - statistics & numerical data; Sexually transmitted diseases; Smallpox; STD; Transgender persons; United States - epidemiology; Vaccine efficacy; Vaccine Efficacy - statistics & numerical data; Vaccines; Viral Infections; United States; United States > US
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa2215201

In this case–control study based on electronic health record data, 2193 patients with mpox were identified. JYNNEOS vaccine effectiveness was approximately 66% after two doses and 36% after one dose.