Non-apoptotic cell death in malignant tumor cells and natural compounds

• Published in: Cancer letters Vol. 420; pp. 210 - 227
• Main Authors: Ye, Jing, Zhang, Ruonan, Wu, Fan, Zhai, Lijuan, Wang, Kaifeng, Xiao, Mang, Xie, Tian, Sui, Xinbing
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.04.2018; Elsevier Limited
• Subjects: Angiogenesis; Apoptosis; Autophagy; Biological Products - chemistry; Biological Products - pharmacology; Biological Products - therapeutic use; Breast cancer; Cancer; Cancer therapies; Cell Death; Cell Line, Tumor; Exosomes - drug effects; Exosomes - metabolism; Ferroptosis; Humans; Kinases; Lymphoma; Mammals; Natural compounds; Necroptosis; Neoplasms - drug therapy; Neoplasms - metabolism; Non-apoptotic cell death; Proteins; Pyroptosis; Signal transduction; Stem cells; Tumor cells; Tumors; Non-apoptotic cell death; Natural compounds; Cancer
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2018.01.061

Traditional cancer therapy is mainly targeting on enhancing cell apoptosis, however, it is well established that many cancer cells are chemo-resistant and defective in apoptosis induction. Therefore, it may have important therapeutic implications to exploit some novel natural compounds based on non-apoptotic programmed cell death. Currently, accumulating evidence shows that the compounds from nature source can induce non-apoptotic programmed cell death in cancer cells, and therefore these natural compounds have gained a great promise for the future anticancer therapeutics. In this review, we will concentrate our efforts on the latest developments regarding major forms of non-apoptotic programmed cell death--autophagic cell death, necroptosis, ferroptosis, pyroptosis, glutamoptosis and exosome-associated cell death. Our increased understanding of the role of natural compounds in regulating non-apoptotic programmed cell death will hopefully provide prospective strategies for cancer therapy. •It is well established that many cancer cells are chemo-resistant and defective in apoptosis induction.•It may have important therapeutic implications to exploit some novel natural compounds based on non-apoptotic programmed cell death.•The compounds from nature source can induce non-apoptotic programmed cell death in cancer cells.•Our increased understanding of the role of natural compounds in regulating non-apoptotic programmed cell death will hopefully provide prospective strategies for cancer therapy.