Reference Values for Peak Exercise Cardiac Output in Healthy Individuals

• Published in: Chest Vol. 151; no. 6; p. 1329
• Main Authors: Agostoni, Piergiuseppe, Vignati, Carlo, Gentile, Piero, Boiti, Costanza, Farina, Stefania, Salvioni, Elisabetta, Mapelli, Massimo, Magrì, Damiano, Paolillo, Stefania, Corrieri, Nicoletta, Sinagra, Gianfranco, Cattadori, Gaia
• Format: Journal Article
• Language: English
• Published: United States 01.06.2017
• Subjects: Adolescent; Adult; Aged; Cardiac Output - physiology; Exercise - physiology; Exercise Test; Female; Healthy Volunteers; Humans; Male; Middle Aged; Oxygen Consumption - physiology; Reference Values; Young Adult; cardiac output; oxygen consumption; exercise
• ISSN: 1931-3543
• DOI: 10.1016/j.chest.2017.01.009

Cardiac output (Q˙) is a key parameter in the assessment of cardiac function, its measurement being crucial for the diagnosis, treatment, and prognostic evaluation of all heart diseases. Until recently, Q˙ determination at peak exercise has been possible through invasive methods, so that normal values were obtained in studies based on small populations. Nowadays, peak Q˙ can be measured noninvasively by means of the inert gas rebreathing (IGR) technique. The present study was undertaken to provide reference values for peak Q˙ in the normal general population and to obtain a formula able to estimate peak exercise Q˙ from measured peak oxygen uptake (V˙o ). We studied 500 normal subjects (age, 44.9 ± 1.5 years; range, 18-77 years; 260 men, 240 women) who underwent a maximal cardiopulmonary exercise test with peak Q˙ measurement by IGR. In the overall study sample, peak Q˙ was 13.2 ± 3.5 L/min (men, 15.3 ± 3.3 L/min; women, 11.0 ± 2.0 L/min; P < .001) and peak V˙o was 95% ± 18% of the maximum predicted value (men, 95% ± 19%; women, 95% ± 18%). Peak V˙o and peak Q˙ progressively decreased with age (R , 0.082; P < .001; and R , 0.144; P < .001, respectively). The V˙o -derived formula to measure Q˙ at peak exercise was (4.4 × peak V˙o ) + 4.3 in the overall study cohort, (4.3 × peak V˙o ) + 4.5 in men, and (4.9 × peak V˙o ) + 3.6 in women. The simultaneous measurement of Q˙ and V˙o at peak exercise in a large sample of healthy subjects provided an equation to predict peak Q˙ from peak V˙o values.