comparative analysis of envelope and tegument proteins of suid herpesvirus 1, bovine herpesvirus 1 and bovine herpesvirus 5

• Published in: Archives of virology Vol. 155; no. 10; pp. 1687 - 1692
• Main Authors: Fonseca, A. A. Jr, Heinemann, M. B, Leite, R. C, Reis, J. K. P
• Format: Journal Article
• Language: English
• Published: Vienna Vienna : Springer Vienna 01.10.2010; Springer Vienna; Springer; Springer Nature B.V
• Subjects: Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Bovine herpesvirus 1; Bovine herpesvirus 5; Brief Report; Evolution, Molecular; Fundamental and applied biological sciences. Psychology; Herpesvirus 1, Bovine - genetics; Herpesvirus 1, Suid - genetics; Herpesvirus 5, Bovine - genetics; Infectious Diseases; Medical Microbiology; Microbiology; Miscellaneous; Protein Conformation; Sequence Homology; Suid herpesvirus; Viral Structural Proteins - genetics; Virology; Vulvovaginitis; Rhinotracheitis; Tegument Protein; Bovine Herpesvirus; Envelope Protein; Virus; Herpesviridae; Alphaherpesvirinae; Bovine herpesvirus 1; Zoopathogen; Veterinary; Protein
• ISSN: 0304-8608; 1432-8798
• DOI: 10.1007/s00705-010-0747-4

The aim of this study was to analyze the disordered regions (DRs) in the envelope and tegument proteins of three closely related herpesviruses: bovine herpesvirus 1, bovine herpesvirus 5 and suid herpesvirus 1. Tegument proteins showed a greater percentage of DRs than the envelope proteins did. Regions of disorder were found in the less conserved portions of the proteins, N-terminal and C-terminal regions, and, in a few cases, functionally important sites. The presence of DRs is an important factor in the evolution of viruses, representing points where positive pressure led to structural changes.