Hepatoprotective activity of Emblica officinalis and Chyavanaprash

• Published in: Journal of ethnopharmacology Vol. 72; no. 1; pp. 135 - 140
• Main Authors: Jose, Jeena K, Kuttan, Ramadasan
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.09.2000; Elsevier
• Subjects: Animals; Biological and medical sciences; Carbon Tetrachloride Poisoning - prevention & control; Chemical and Drug Induced Liver Injury - prevention & control; Chyavanaprash; Collagen - metabolism; Emblica officinalis; General pharmacology; Hepatoprotection; Herbal drugs; Hydroxyproline - metabolism; India; Lipid Peroxidation - drug effects; Liver Cirrhosis, Experimental - chemically induced; Liver Cirrhosis, Experimental - prevention & control; Liver Function Tests; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - therapeutic use; Plants, Medicinal - chemistry; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances - metabolism; Hepatoprotection; Chyavanaprash; Emblica officinalis; Herbal drugs; Rat; Hepatoprotector; Toxicity; Liver; Carbon tetrachloride; Extract; Medicinal plant; Prevention; Dicotyledones; Angiospermae; Euphorbiaceae; Phytotherapy; Fruit; Pharmacognosy; Acute; Rodentia; Antioxidant; Biological activity; Vertebrata; Chronic; Mammalia; Treatment; Animal; Plant origin; Spermatophyta
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(00)00219-1

Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CHY) extracts were studied using carbon tetrachloride (CCl 4) induced liver injury model in rats. EO and CHY extracts were found to inhibit the hepatotoxicity produced by acute and chronic CCl 4 administration as seen from the decreased levels of serum and liver lipid peroxides (LPO), glutamate-pyruvate transaminase (GPT), and alkaline phosphatase (ALP). Chronic CCl 4 administration was also found to produce liver fibrosis as seen from the increased levels of collagen-hydroxyproline and pathological analysis. EO and CHY extracts were found to reduce these elevated levels significantly, indicating that the extract could inhibit the induction of fibrosis in rats.