Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat

• Published in: European journal of pharmacology Vol. 404; no. 1; pp. 169 - 174
• Main Authors: Farzin, Davood, Attarzadeh, Maryam
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.09.2000; Elsevier
• Subjects: Animals; Apomorphine; Apomorphine - pharmacology; Biological and medical sciences; Cell receptors; Cell structures and functions; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Chlorpheniramine - pharmacology; Dimaprit - pharmacology; Diphenhydramine - pharmacology; Dopamine Agonists - pharmacology; Drug Interactions; Famotidine - pharmacology; Fundamental and applied biological sciences. Psychology; Histamine; Histamine - analogs & derivatives; Histamine - pharmacology; Histamine Agonists - pharmacology; Histamine Antagonists - pharmacology; Imidazoles - pharmacology; Licking behavior; Male; Molecular and cellular biology; Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine); Piperidines - pharmacology; Ranitidine - pharmacology; Rat; Rats; Rats, Sprague-Dawley; Stereotyped Behavior - drug effects; Thiourea - analogs & derivatives; Thiourea - pharmacology; Toluidines - pharmacology; Vertebrates: nervous system and sense organs; Histamine; Licking behavior; Rat; Apomorphine; Agonist; Histaminergic pathway; Rodentia; Antihistaminic; Neuromodulation; Vertebrata; Mammalia; Animal; Dopamine agonist; Antagonist; H1 Histamine receptor; H2 Histamine receptor; H3 Histamine receptor
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/S0014-2999(00)00608-7

The effects of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats were investigated. Subcutaneous (s.c.) injection of various doses of apomorphine (0.125–1.25 mg/kg) induced licking. The licking response was counted by direct observation and recorded for a 75-min period. Intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) injection of the histamine H 1 or H 2 receptor agonist, HTMT (6-[2-(4-imidazolyl)ethylamino]- N-(4-trifluoromethylphenyl) heptanecarboxamide) (50 and 100 μg per rat), or dimaprit (10 and 15 mg/kg, i.p.), respectively, potentiated apomorphine-induced licking, while the histamine H 3 receptor agonist, imetit (5 and 10 mg/kg, i.p.), reduced the licking response induced by apomorphine. Pretreatment with various histamine receptor antagonists, dexchlorpheniramine (30 and 40 mg/kg, i.p.), diphenhydramine (20, 30 and 40 mg/kg, i.p.), famotidine (30 and 40 mg/kg, s.c.) and ranitidine (20, 30 and 40 mg/kg), reduced apomorphine-induced licking, while thioperamide (5 and 10 mg/kg, i.p.) potentiated the apomorphine effect. The effects of HTMT and dimaprit were blocked by dexchlorpheniramine (20 mg/kg, i.p.) and famotidine (20 mg/kg, s.c.), respectively. The inhibitory effect elicited by imetit on apomorphine-induced licking behavior was also abolished in animals treated with thioperamide (2.5 mg/kg, i.p.). The results suggest that histaminergic mechanisms may be involved in the modulation of apomorphine-induced licking behavior.