Hypophosphataemia in the metabolic syndrome. Gender differences in body weight and blood glucose

• Published in: European journal of clinical nutrition Vol. 55; no. 6; pp. 493 - 498
• Main Authors: HAGLIN, L, LINDBLAD, A, BYGREN, L. O
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01.06.2001; Nature Publishing Group
• Subjects: Biological and medical sciences; Blood; Blood Glucose - metabolism; Blood Pressure; Body Mass Index; Body size; Body weight; Body Weight - physiology; Calcium - blood; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Clinical nutrition; Cluster Analysis; Clustering; Complications and side effects; Correlation; Diabetes. Impaired glucose tolerance; Education; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gender; Gender aspects; Gender differences; Glucose; Health risks; Heart diseases; High density lipoprotein; Humans; Hypophosphatemia; Lipids; Lipids - blood; Male; Medical sciences; Medicin och hälsovetenskap; Men; Metabolic disorders; Metabolic syndrome; Metabolism; Middle Aged; Nutrition; Obesity; Obesity - blood; Obesity - physiopathology; Oxygen Consumption; Phosphates - blood; Risk analysis; Risk Factors; Sex differences; Sex Factors; Sexes; Uric acid; Women; Sweden; Endocrinopathy; Human; Hydroelectrolytic balance disorder; Pathophysiology; Body weight; Sex; Cardiovascular disease; Metabolic diseases; Inorganic element; Body mass index; Metabolic disorder; X Syndrome; Hypophosphatemia; Blood pressure; Comparative study; Glycemia
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1601209

We examined gender differences in the clustering of risk factors, especially regarding the possible role of serum phosphate (S-P) in obese patients who participated in a 4 week education programme to reduce their excess risk of cardiovascular disease (CVD). Significantly higher body mass index (BMI) and concentrations of S-P and high density lipids (S-HDL) in serum were found in women (n=1272) than in men (n=993). In women, BMI was inversely correlated with S-P at the time of admission. Also in women (but not in men), changes in BMI and S-P over 1 or 1-1/2 y were inversely correlated. In men (but not in women), S-P level was inversely correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP) and blood glucose at the time of admission. In women, S-P increased and DBP decreased, in addition to weight decrease over both 6 months and 1(1/2) y or 1 y. In women (but not in men), significantly higher age, S-P, S-chol, S-TG, S-urate, SBP and DBP values were found with the highest vs the lowest decile of S-Ca. We conclude that higher S-P and S-Ca levels may contribute to the difference in metabolic disturbances occurring in obesity, seen in women vs men.