The Absence of uPAR Is Associated with the Progression of Dermal Fibrosis

• Published in: Journal of investigative dermatology Vol. 128; no. 12; pp. 2792 - 2797
• Main Authors: Kanno, Yosuke, Kaneiwa, Aki, Minamida, Misato, Kanno, Miho, Tomogane, Kanji, Takeuchi, Koji, Okada, Kiyotaka, Ueshima, Shigeru, Matsuo, Osamu, Matsuno, Hiroyuki
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2008; Nature Publishing Group; Elsevier Limited
• Subjects: Animals; Biological and medical sciences; Cell Proliferation; Collagen - metabolism; Dermatology; Extracellular Matrix - metabolism; Female; Fibrinolysis; Fibroblasts - metabolism; Fibrosis - pathology; Male; Medical sciences; Mice; Mice, Transgenic; Microscopy, Electron, Scanning; Models, Biological; Receptors, Urokinase Plasminogen Activator - genetics; Receptors, Urokinase Plasminogen Activator - physiology; Skin - pathology; Association; Prognosis; Dermatology; Fibrosis; Evolution; Skin; Derm

The fibrinolytic system is considered to play an important role in the degradation of extracellular matrices (ECM). However, the detailed mechanism regarding how this system affects fibrosis remains unclear. Urokinase-type plasminogen activator receptor (uPAR) not only functions as a proteinase rece...