Glyceollin, a soybean phytoalexin with medicinal properties

• Published in: Applied microbiology and biotechnology Vol. 90; no. 1; pp. 59 - 68
• Main Authors: Ng, Tzi Bun, Ye, Xiu Juan, Wong, Jack Ho, Fang, Evandro Fei, Chan, Yau Sang, Pan, Wenliang, Ye, Xiu Yun, Sze, Stephen Cho Wing, Zhang, Kalin Yanbo, Liu, Fang, Wang, He Xiang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.04.2011; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Animals; Anti-Infective Agents - metabolism; Anti-Infective Agents - pharmacology; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Apoptosis; Biological and medical sciences; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Bradyrhizobium japonicum; Cancer therapies; Cell death; Cercospora; Cloning; Cyclin-dependent kinases; Diaporthe phaseolorum; Drug Therapy; E coli; Enzymes; Erwinia carotovora; Escherichia coli; Estrogens; Functional foods & nutraceuticals; Fundamental and applied biological sciences. Psychology; Fusarium solani; Genes; Glyceollin; Glycine max - chemistry; Glycine max - metabolism; Herbicides; Humans; Kinases; Life Sciences; Macrophomina phaseolina; Medisin; Melanoma; Metabolism; Microbial Genetics and Genomics; Microbiology; Mini-Review; Ovarian cancer; Pathogens; Phialophora gregata; Phytoalexin; Phytoalexins; Phytophthora sojae; Prostate cancer; Proteins; Pterocarpans - biosynthesis; Pterocarpans - pharmacology; Rhizoctonia solani; Sesquiterpenes - metabolism; Sesquiterpenes - pharmacology; Sinorhizobium fredii; Soybeans; Studies; Medisin; Glyceollin; Soybean; Phytoalexin
• ISSN: 0175-7598; 1432-0614
• DOI: 10.1007/s00253-011-3169-7

This review covers the biosynthesis of glyceollin and its biological activities including antiproliferative/antitumor action (toward B16 melanoma cells, LNCaP prostate cancer cells, and BG-1 ovarian cancer cells), anti-estrogenic action (through estrogen receptors α- and β-), antibacterial action (toward Erwinia carotovora, Escherichia coli, Bradyrhizobium japonicum, Sinorhizobium fredii ), antinematode activity, and antifungal activity (toward Fusarium solani, Phakospora pachyrhizi, Diaporthe phaseolorum, Macrophomina phaseolina, Sclerotina sclerotiorum, Phytophthora sojae, Cercospora sojina, Phialophora gregata, and Rhizoctonia solani). Other activities include insulinotropic action and attenuation of vascular contractions in rat aorta.