Reanalysis of Coreceptor Tropism in HIV-1—Infected Adults Using a Phenotypic Assay with Enhanced Sensitivity

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell...

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Bibliographic Details
Published inClinical infectious diseases Vol. 52; no. 7; pp. 925 - 928
Main Authors Wilkin, Timothy J., Goetz, Mathew Bidwell, Leduc, Robert, Skowron, Gail, Su, Zhaohui, Chan, Ellen S., Heera, Jayyant, Chapman, Doug, Spritzler, John, Reeves, Jacqueline D., Gulick, Roy M., Coakley, Eoin
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.04.2011
Subjects
Adult
Adults
AIDS
Arts
BRIEF REPORT
Cells
Clinical research
Clinical trials
Genotype & phenotype
HIV
HIV 1
HIV Infections - virology
HIV-1 - physiology
HIV/AIDS
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Patients
Receptors, CCR5 - metabolism
Receptors, CXCR4 - metabolism
Receptors, HIV - metabolism
RNA
T cell receptors
Tropisms
Viral Tropism
Virology - methods
Virus Attachment
Viruses
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Summary:The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CSCR4-using virus in all cohorts.
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ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/cir072