Towards single cell encapsulation for precision biology and medicine

[Display omitted] The primary impetus of therapeutic cell encapsulation in the past several decades has been to broaden the options for donor cell sources by countering against immune-mediated rejection. However, another significant advantage of encapsulation is to provide donor cells with physiolog...

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Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 201; p. 115010
Main Authors Gupta, Prerak, Alheib, Omar, Shin, Jae-Won
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2023
Subjects
Biocompatible Materials
Biology
Cell Encapsulation
Cell therapy
Extracellular matrix
Humans
Microencapsulation
Precision medicine
Single cell biology
Single cell encapsulation
Single cell biology
Single cell encapsulation
Extracellular matrix
Microencapsulation
Cell therapy
Precision medicine
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Summary:[Display omitted] The primary impetus of therapeutic cell encapsulation in the past several decades has been to broaden the options for donor cell sources by countering against immune-mediated rejection. However, another significant advantage of encapsulation is to provide donor cells with physiologically relevant cues that become compromised in disease. The advances in biomaterial design have led to the fundamental insight that cells sense and respond to various signals encoded in materials, ranging from biochemical to mechanical cues. The biomaterial design for cell encapsulation is becoming more sophisticated in controlling specific aspects of cellular phenotypes and more precise down to the single cell level. This recent progress offers a paradigm shift by designing single cell-encapsulating materials with predefined cues to precisely control donor cells after transplantation.
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Author contributions
P.G., O.A., and J.-W.S. researched data for the article and wrote the article. All authors contributed substantially to discussion of the content and reviewed the manuscript before submission.
ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2023.115010