Pathologic hepatic Tc-99m-MDP uptake in polyostotic fibrous dysplasia

• Published in: Annals of nuclear medicine Vol. 18; no. 7; pp. 627 - 630
• Main Authors: Kekilli, Ersoy, Yagmur, Cengiz, Kuzucu, Akin, Soysal, Omer, Cikim, Ayse Sertkaya, Ertem, Kadir
• Format: Journal Article
• Language: English
• Published: Japan Springer Nature B.V 01.10.2004
• Subjects: Adult; Bisphosphonates; Bone dysplasia; Calcium oxalate; Calcium phosphates; Chest Pain - diagnosis; Chest Pain - etiology; Connective tissue diseases; Connective tissues; Cranium; Crystals; Developmental disabilities; Fibrous dysplasia; Fibrous Dysplasia, Polyostotic - diagnostic imaging; Fibrous Dysplasia, Polyostotic - metabolism; Humans; Incidental Findings; Liver; Liver - diagnostic imaging; Liver - metabolism; Male; Pamidronic acid; Radionuclide Imaging; Radiopharmaceuticals - pharmacokinetics; Scintigraphy; Skull; Technetium Tc 99m Medronate - pharmacokinetics; Vertebrae
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/BF02984586

Fibrous dysplasia of bone is a congenital, sporadic developmental disorder characterized by immature fibrous connective tissue and bone deformities. Hepatic Tc-99m-MDP uptake is a rare, serendipitous finding during bone scanning studies. The present patient was a 25-year-old male who had severe polyostotic fibrous dysplasia. On Tc-99m-MDP (methylene diphosphonate) bone scintigraphy, increased activity accumulations were seen on multiple ribs, vertebrae and base of the cranium. In addition, diffuse increased pathologic uptake of Tc-99m-MDP in the liver was shown. Intravenous pamidronate was administered monthly for two months. In the third week of the last administration Tc-99m-MDP bone scintigraphy was performed again, but despite sustained bone involvement, pathologic hepatic uptake was not seen on the scan. We thought that pathologic hepatic Tc-99m-MDP accumulation, may be related to the formation and aggregation of calcium oxalate and phosphate crystals which improved with pamidromat treatment.