Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats

• Published in: Asian Pacific journal of tropical medicine Vol. 6; no. 12; pp. 986 - 989
• Main Authors: Liu, Hong-Bo, Lin, Chun-Hua, Zhou, Guang-Yu, Chen, Guo-Zhen, Cai, Wei-Yan
• Format: Journal Article
• Language: English
• Published: India Elsevier B.V 01.12.2013; Yuhuangding Hospital of Yantai, Yantai 264000, Shandong Province, China
• Subjects: Animals; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Blood Pressure - drug effects; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Female; Hypertension; Hypertension - drug therapy; hypertrophy; Left; Left ventricular hypertrophy; Male; Metoprolol - pharmacology; Metoprolol - therapeutic use; Myocardium - chemistry; Myocardium - pathology; Rats; Rats, Wistar; ventricular; Ventricular Remodeling - drug effects; Xinjikang; Hypertension; Rats; Xinjikang; Left ventricular hypertrophy
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(13)60177-7

Objective:To investigate the effects of Xinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.Methods:Sixty Wistar rats were randomly divided into four groups.The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligation method.Rats in A and B groups were intragastrically administered with physiological saline,while C and D groups were administered with Xinjikang and metoprolol,respectively.The changes in blood pressure.E/A ratio,myocardial pathological morphology,myocardial lipoperoxides and superoxide dismustase activity in four groups were observed and compared before and after treatment.Results:There were statistically significant differences in E/A ratio between C group after treatment and model group(P<0.05).while no difference was observed between A and D groups(P>0.05);after treatment the myocardial lipoperoxides and superoxide dismustase contents in C and D groups were improved significantly compared with model group(P<0.05).Conclusions:Xinjikang can improve myocardial injury,restore myocardial parenchyma and myocardial interstitial remodeling functions in hypertensive rats with the left ventricular hypertrophy.