CTAB–tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] interaction: a tool for predicting organotin(IV) complex–cell membrane interaction parameters
This study attempts to explain the bioavailability, permeability, and interaction parameters of organotin(IV) derivatives with the cell membrane. For this purpose, tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] was synthesized and characterized by elemental analysis and spectroscopic metho...
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Published in | Colloid and polymer science Vol. 294; no. 1; pp. 87 - 94 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.01.2016
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | This study attempts to explain the bioavailability, permeability, and interaction parameters of organotin(IV) derivatives with the cell membrane. For this purpose, tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] was synthesized and characterized by elemental analysis and spectroscopic methods (Fourier transform infrared spectroscopy (FT-IR),
1
H,
13
C,
119
Sn NMR). The organic anion was found to act as monodentate O-bound ligand in solution. Cationic surfactant cetyl
N
,
N
,
N
-trimethylammoniumbromide (CTAB) was used to study the interactions of the organotin(IV) complex with positively charged molecules of the surfactant acting as a model cell membrane. The thermodynamic parameters of complex–CTAB interaction concluded that the complex is located in the peripheral region of CTAB micelles. The redshifts in the UV spectra of the complex confirmed its solubilization into micelles. The two carbonyl oxygen atoms were found to be binding sites of the complex with CTAB. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0303-402X 1435-1536 |
DOI: | 10.1007/s00396-015-3738-x |