CTAB–tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] interaction: a tool for predicting organotin(IV) complex–cell membrane interaction parameters

• Published in: Colloid and polymer science Vol. 294; no. 1; pp. 87 - 94
• Main Authors: Shah, Farooq Ali, Khan, Asad Muhammad, Sabir, Shaista, Ali, Saqib
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2016; Springer Nature B.V
• Subjects: Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Food Science; Fourier transforms; Infrared spectroscopy; Interaction parameters; Mathematical models; Membranes; Micelles; Nanotechnology and Microengineering; Original Contribution; Physical Chemistry; Polymer Sciences; Soft and Granular Matter; Surfactants; Organotin(IV) carboxylates; Drug delivery; Critical micelle concentration; Bioavailability; CTAB; Thermodynamics parameters
• ISSN: 0303-402X; 1435-1536
• DOI: 10.1007/s00396-015-3738-x

This study attempts to explain the bioavailability, permeability, and interaction parameters of organotin(IV) derivatives with the cell membrane. For this purpose, tributylstannic[3-(3′,4′-dichlorophenylamido)propanoate] was synthesized and characterized by elemental analysis and spectroscopic methods (Fourier transform infrared spectroscopy (FT-IR), 1 H, 13 C, 119 Sn NMR). The organic anion was found to act as monodentate O-bound ligand in solution. Cationic surfactant cetyl N , N , N -trimethylammoniumbromide (CTAB) was used to study the interactions of the organotin(IV) complex with positively charged molecules of the surfactant acting as a model cell membrane. The thermodynamic parameters of complex–CTAB interaction concluded that the complex is located in the peripheral region of CTAB micelles. The redshifts in the UV spectra of the complex confirmed its solubilization into micelles. The two carbonyl oxygen atoms were found to be binding sites of the complex with CTAB.