Pharmacokinetic Studies of the Fragrance Compound 1,8-Cineol in Humans during Inhalation

The present study was undertaken to investigate the pharmacokinetics of 1,8-cineol in human subjects during prolonged inhalation. The results showed that 1,8-cineol is well absorbed from breathing air, with a peak plasma concentration after ∼18 min. The elimination of this fragrance compound from th...

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Bibliographic Details
Published inChemical senses Vol. 21; no. 4; pp. 477 - 480
Main Authors Jāger, W., Našel, B., Našel, C., Binder, R., Stimpfl, T., Vycudilik, W., Buchbauer, G.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford Oxford University Press 01.08.1996
Subjects
Administration, Inhalation
Adult
Behavioral psychophysiology
Biological and medical sciences
Cyclohexanols
Eucalyptol
Female
Fundamental and applied biological sciences. Psychology
Half-Life
Humans
Male
Menthol - administration & dosage
Menthol - analogs & derivatives
Menthol - pharmacokinetics
Miscellaneous
Monoterpenes
Perfume
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Terpenes
Human
Blood concentration
Perfume
Elimination
Olfaction
Sex
Perception
Rosemary
Essential oil
Pharmacokinetics
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Summary:The present study was undertaken to investigate the pharmacokinetics of 1,8-cineol in human subjects during prolonged inhalation. The results showed that 1,8-cineol is well absorbed from breathing air, with a peak plasma concentration after ∼18 min. The elimination of this fragrance compound from the blood is biphasic, with a mean distribution half-life of 6.7 min and an elimination half-life of 104.6 min. Chem. Senses 21: 477–480, 1996.
Bibliography:istex:A564B2A1126A51B2E2C722E10CFB04824D13409E
Correspondence to be sent to: Walter Jäger, Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
ArticleID:21.4.477
ark:/67375/HXZ-P6Z0V3CN-R
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SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ObjectType-Article-1
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ISSN:0379-864X
1464-3553
DOI:10.1093/chemse/21.4.477