Maternal KIR repertoire is not associated with recurrent spontaneous abortion
BACKGROUND: In view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells present in the pregnant uterus, we investigated the genetic polymorphism of the killer cell immunoglobulin-like receptors (KIR) in wom...
Saved in:
Published in | Human reproduction (Oxford) Vol. 19; no. 11; pp. 2653 - 2657 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.11.2004
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | BACKGROUND: In view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells present in the pregnant uterus, we investigated the genetic polymorphism of the killer cell immunoglobulin-like receptors (KIR) in women with RSA. METHODS: KIR gene repertoire and KIR2DL4 (a receptor for HLA-G) genotyping were determined by SSP and SSCP respectively, in women experiencing RSA and controls. RESULTS: The KIR repertoire did not differ between RSA patients and controls in terms of: (i) the number of inhibitory receptors; (ii) the number of activating receptors; (iii) the ratio of inhibitory to activating receptors. KIR2DL4, a receptor for HLA-G, has different transmembrane alleles, which produce functionally different phenotypes. The frequency of KIR2DL4 transmembrane genotypes differed significantly between RSA patients and controls (P=0.03). However, although homozygosity for a membrane-bound receptor was more frequent in patients (25%) than controls (10%), other genotypes that would produce the same phenotype were not more frequent in patients than controls. CONCLUSIONS: The data provide little evidence that KIR polymorphism plays a role in predisposition to RSA. |
---|---|
AbstractList | BACKGROUND: In view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells present in the pregnant uterus, we investigated the genetic polymorphism of the killer cell immunoglobulin-like receptors (KIR) in women with RSA. METHODS: KIR gene repertoire and KIR2DL4 (a receptor for HLA-G) genotyping were determined by SSP and SSCP respectively, in women experiencing RSA and controls. RESULTS: The KIR repertoire did not differ between RSA patients and controls in terms of: (i) the number of inhibitory receptors; (ii) the number of activating receptors; (iii) the ratio of inhibitory to activating receptors. KIR2DL4, a receptor for HLA-G, has different transmembrane alleles, which produce functionally different phenotypes. The frequency of KIR2DL4 transmembrane genotypes differed significantly between RSA patients and controls (P=0.03). However, although homozygosity for a membrane-bound receptor was more frequent in patients (25%) than controls (10%), other genotypes that would produce the same phenotype were not more frequent in patients than controls. CONCLUSIONS: The data provide little evidence that KIR polymorphism plays a role in predisposition to RSA. BACKGROUNDIn view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells present in the pregnant uterus, we investigated the genetic polymorphism of the killer cell immunoglobulin-like receptors (KIR) in women with RSA.METHODSKIR gene repertoire and KIR2DL4 (a receptor for HLA-G) genotyping were determined by SSP and SSCP respectively, in women experiencing RSA and controls.RESULTSThe KIR repertoire did not differ between RSA patients and controls in terms of: (i) the number of inhibitory receptors; (ii) the number of activating receptors; (iii) the ratio of inhibitory to activating receptors. KIR2DL4, a receptor for HLA-G, has different transmembrane alleles, which produce functionally different phenotypes. The frequency of KIR2DL4 transmembrane genotypes differed significantly between RSA patients and controls (P=0.03). However, although homozygosity for a membrane-bound receptor was more frequent in patients (25%) than controls (10%), other genotypes that would produce the same phenotype were not more frequent in patients than controls.CONCLUSIONSThe data provide little evidence that KIR polymorphism plays a role in predisposition to RSA. In view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells present in the pregnant uterus, we investigated the genetic polymorphism of the killer cell immunoglobulin-like receptors (KIR) in women with RSA. KIR gene repertoire and KIR2DL4 (a receptor for HLA-G) genotyping were determined by SSP and SSCP respectively, in women experiencing RSA and controls. The KIR repertoire did not differ between RSA patients and controls in terms of: (i) the number of inhibitory receptors; (ii) the number of activating receptors; (iii) the ratio of inhibitory to activating receptors. KIR2DL4, a receptor for HLA-G, has different transmembrane alleles, which produce functionally different phenotypes. The frequency of KIR2DL4 transmembrane genotypes differed significantly between RSA patients and controls (P=0.03). However, although homozygosity for a membrane-bound receptor was more frequent in patients (25%) than controls (10%), other genotypes that would produce the same phenotype were not more frequent in patients than controls. The data provide little evidence that KIR polymorphism plays a role in predisposition to RSA. |
Author | Daher, S. Christiansen, F.T. Goodridge, J. Witt, C.S. Gerbase-DeLima, M.G. |
Author_xml | – sequence: 1 givenname: C.S. surname: Witt fullname: Witt, C.S. organization: Department of Clinical Immunology, Royal Perth Hospital, Perth, West Australia, 6000 – sequence: 2 givenname: J. surname: Goodridge fullname: Goodridge, J. organization: School of Surgery and Pathology, University of West Australia, Perth, West Australia, 6912 – sequence: 3 givenname: M.G. surname: Gerbase-DeLima fullname: Gerbase-DeLima, M.G. organization: Immunogenetics Division, Pediatrics Department, Universidade Federal de São Paulo – sequence: 4 givenname: S. surname: Daher fullname: Daher, S. organization: Obstetrics Department, Universidade Federal de Sao Paulo, Brazil – sequence: 5 givenname: F.T. surname: Christiansen fullname: Christiansen, F.T. organization: Department of Clinical Immunology, Royal Perth Hospital, Perth, West Australia, 6000 |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16225543$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15333596$$D View this record in MEDLINE/PubMed |
BookMark | eNqF0M1LHDEYBvBQLHW1PfZaBkHxMprvyRyr-IUuwraF4iVkkgwbnU2mSQb1v3eWGSr00tObw48n7_vsgR0fvAXgK4InCNbkdD1sou1PjV1TQT6ABaIclpgwuAMWEHNRIsTRLthL6RHC8Sn4J7CLGCGE1XwBlkuVbfSqK25vVsWYZGMOLtrCpcKHXKiUgnajMcWzy-tR6CFG63OR-uCz8jYMqVBNiNkF_xl8bFWX7Jd57oNflxc_z6_Lu_urm_Pvd6WmjOdSMaFVzRpLW8ONUpQixhmrKqx4Q2CDcMsqUWurW4OFaTFtmpoSUzPTMEw42QdHU24fw5_Bpiw3LmnbddM-kvO6JlBUIzz4Bz6GYXtukhghwbCgaETlhHQMKUXbyj66jYqvEkG5LVlOJcup5NF_m0OHZmPNu55bHcHhDFTSqmuj8tqld8cxZoxug44nF4b-v3_OO7qU7ctfrOKT5BWpmLz-_SDZ2Wq1_HF1Kx_IG6mlpkE |
CODEN | HUREEE |
CitedBy_id | crossref_primary_10_3390_biomedicines9101425 crossref_primary_10_1007_s00005_016_0389_7 crossref_primary_10_1016_S1472_6483_10_62012_3 crossref_primary_10_3389_fimmu_2022_868175 crossref_primary_10_1016_j_jri_2010_11_001 crossref_primary_10_1038_cmi_2014_62 crossref_primary_10_1016_j_acthis_2009_12_001 crossref_primary_10_1093_humrep_dep047 crossref_primary_10_1146_annurev_immunol_102119_075119 crossref_primary_10_1111_j_1600_0897_2007_00469_x crossref_primary_10_1016_j_fertnstert_2005_05_012 crossref_primary_10_1016_j_smim_2008_06_003 crossref_primary_10_3390_jcm12041355 crossref_primary_10_37349_ei_2022_00077 crossref_primary_10_1093_molehr_gah181 crossref_primary_10_1007_BF03195699 crossref_primary_10_1016_j_jri_2023_104188 crossref_primary_10_1111_tan_12452 crossref_primary_10_1097_GRF_0000000000000215 crossref_primary_10_7124_FEEO_v21_863 crossref_primary_10_1016_j_jgyn_2012_07_001 crossref_primary_10_1111_aji_12453 crossref_primary_10_4049_jimmunol_1301748 crossref_primary_10_1111_j_1600_0897_2009_00709_x crossref_primary_10_1016_j_bbrc_2007_06_125 crossref_primary_10_1111_j_1399_0039_2010_01451_x crossref_primary_10_1111_j_1600_0897_2005_00268_x crossref_primary_10_1111_j_1600_0897_2008_00593_x crossref_primary_10_1111_j_1399_0039_2006_00782_x crossref_primary_10_1016_j_jri_2020_103186 crossref_primary_10_1007_s00251_017_1003_9 crossref_primary_10_1016_j_fertnstert_2007_07_1331 crossref_primary_10_1093_humrep_den011 crossref_primary_10_1111_j_1600_0897_2008_00596_x crossref_primary_10_1007_s10815_012_9811_1 crossref_primary_10_1093_humrep_deq341 crossref_primary_10_1016_j_ejogrb_2008_04_011 crossref_primary_10_1016_j_jri_2021_103425 crossref_primary_10_1093_humrep_dep217 crossref_primary_10_1111_imr_13087 crossref_primary_10_1007_s10815_019_01426_9 crossref_primary_10_1093_humupd_dmr043 crossref_primary_10_4049_jimmunol_1302079 crossref_primary_10_3892_etm_2021_10612 crossref_primary_10_1089_gtmb_2019_0224 crossref_primary_10_1038_sj_gene_6364256 crossref_primary_10_1111_j_1600_0897_2009_00688_x crossref_primary_10_1093_humrep_dep216 |
Cites_doi | 10.1111/j.1399-0039.2004.00170.x 10.1016/S0165-0378(02)00059-1 10.1002/1521-4141(200201)32:1<18::AID-IMMU18>3.0.CO;2-7 10.1016/S1074-7613(00)80394-5 10.1002/1521-4141(200006)30:6<1623::AID-IMMU1623>3.0.CO;2-M 10.1016/S0161-5890(97)00032-1 10.4049/jimmunol.171.4.1768 10.1111/j.1600-0897.1999.tb00447.x 10.1073/pnas.96.10.5674 10.1002/eji.200323741 10.1084/jem.189.7.1093 10.1053/plac.1999.0496 10.1016/S0165-0378(03)00046-9 10.1095/biolreprod56.1.169 10.1016/S0165-0378(01)00111-5 10.1034/j.1600-0897.2003.00018.x 10.1093/molehr/7.12.1167 10.1210/jc.86.4.1823 10.1002/eji.1830270426 10.1111/j.1469-1809.1995.tb01608.x 10.4049/jimmunol.167.4.1877 10.1034/j.1399-0039.2002.590302.x 10.1034/j.1399-0039.2000.560307.x 10.1007/s004410050713 10.4049/jimmunol.171.7.3415 10.1111/j.1600-0897.1999.tb00462.x 10.1084/jem.192.2.259 10.1016/S0165-0378(97)00073-9 |
ContentType | Journal Article |
Copyright | Human Reproduction vol. 19 no. 11 © European Society of Human Reproduction and Embryology 2004; all rights reserved 2004 2004 INIST-CNRS Copyright Oxford University Press(England) Nov 2004 |
Copyright_xml | – notice: Human Reproduction vol. 19 no. 11 © European Society of Human Reproduction and Embryology 2004; all rights reserved 2004 – notice: 2004 INIST-CNRS – notice: Copyright Oxford University Press(England) Nov 2004 |
DBID | BSCLL IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 8FD FR3 K9. P64 RC3 7X8 |
DOI | 10.1093/humrep/deh483 |
DatabaseName | Istex Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Nucleic Acids Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Health & Medical Complete (Alumni) Genetics Abstracts Engineering Research Database Technology Research Database Nucleic Acids Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1460-2350 |
EndPage | 2657 |
ExternalDocumentID | 729615181 10_1093_humrep_deh483 15333596 16225543 10.1093/humrep/deh483 ark_67375_HXZ_5BRRMSGK_Z |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -E4 .2P .55 .GJ .I3 .XZ .ZR 0R~ 1TH 29I 2WC 3O- 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 6.Y 70D AABJS AABMN AABZA AACZT AAESY AAIMJ AAIYJ AAJKP AAJQQ AAMDB AAMVS AAOGV AAPGJ AAPNW AAPQZ AAPXW AARHZ AASNB AAUQX AAVAP AAVLN AAWDT AAYOK ABEUO ABIXL ABJNI ABKDP ABMNT ABNHQ ABNKS ABPTD ABQLI ABQTQ ABSAR ABSMQ ABWST ABXVV ABZBJ ACCCW ACFRR ACGFS ACIMA ACMRT ACPQN ACPRK ACUFI ACUTJ ACUTO ACYHN ADBBV ADEIU ADEYI ADEZT ADGKP ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADORX ADQLU ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEJOX AEKPW AEKSI AELWJ AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFZL AFGWE AFIYH AFOFC AFXAL AFXEN AFYAG AGINJ AGKEF AGKRT AGQXC AGSYK AGUTN AHMBA AHXPO AIJHB AIKOY AIMBJ AJEEA AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC ANFBD APIBT APWMN AQDSO AQKUS AQVPL ARIXL ASAOO ASMCH ASPBG ATDFG ATTQO AVNTJ AVWKF AWCFO AXUDD AYOIW AZFZN AZQFJ BAWUL BAYMD BCRHZ BEYMZ BGYMP BHONS BQDIO BSCLL BSWAC BTRTY BVRKM BYORX BZKNY C1A C45 CAG CASEJ CDBKE COF CS3 CXTWN CZ4 DAKXR DFGAJ DIK DILTD DPORF DPPUQ DU5 D~K E3Z EBS EE~ EIHJH EJD ELUNK EMOBN ENERS F5P F9B FECEO FEDTE FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H5~ HAR HVGLF HW0 HZ~ IOX J21 JXSIZ KAQDR KBUDW KC5 KOP KQ8 KSI KSN L7B M-Z M49 MBLQV MBTAY MHKGH ML0 N9A NGC NLBLG NOMLY NOYVH NTWIH NU- NVLIB O0~ O9- OAUYM OAWHX OBOKY OCZFY ODMLO OHT OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RIG RNI ROL ROX ROZ RUSNO RW1 RXO RZF RZO TCN TCURE TEORI TJX TLC TMA TR2 W8F WH7 WOQ X7H X7M YAYTL YKOAZ YXANX ZGI ZKX ZXP ~91 AAUAY ABQNK ACZBC ADQBN AFSHK AGMDO ATGXG H13 AANRK AAPBV AAUGY ABPTK ABXZS ALXQX IQODW OBFPC CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 8FD FR3 K9. P64 RC3 7X8 |
ID | FETCH-LOGICAL-c456t-a58ca95be4fd6daa4415655772a6b30b12f5789cecfd28df24bb943d95db52363 |
ISSN | 0268-1161 |
IngestDate | Fri Aug 16 08:53:44 EDT 2024 Fri Sep 13 08:17:10 EDT 2024 Thu Sep 12 18:11:03 EDT 2024 Thu May 23 23:12:37 EDT 2024 Sun Oct 22 16:04:26 EDT 2023 Wed Aug 28 03:20:32 EDT 2024 Sun Mar 31 11:37:58 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Keywords | killer cell immunoglobulin-like receptors recurrent spontaneous abortion NK cell Natural killer cell Vertebrata Immunoglobulins Relapse Mammalia Pregnancy disorders Mother Killer cell Abortion Biological receptor killer cell immunoglobulin-like receptors/NK cell/recurrent spontaneous abortion |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c456t-a58ca95be4fd6daa4415655772a6b30b12f5789cecfd28df24bb943d95db52363 |
Notes | href:deh483.pdf ark:/67375/HXZ-5BRRMSGK-Z local:deh483 istex:7D48C27CEB0A2B9AABC7F480BD9FBFB9678E17DC 6To whom correspondence should be addressed. Email: Campbell.Witt@health.wa.gov.au ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://academic.oup.com/humrep/article-pdf/19/11/2653/6953062/deh483.pdf |
PMID | 15333596 |
PQID | 211852841 |
PQPubID | 36115 |
PageCount | 5 |
ParticipantIDs | proquest_miscellaneous_66993087 proquest_journals_211852841 crossref_primary_10_1093_humrep_deh483 pubmed_primary_15333596 pascalfrancis_primary_16225543 oup_primary_10_1093_humrep_deh483 istex_primary_ark_67375_HXZ_5BRRMSGK_Z |
PublicationCentury | 2000 |
PublicationDate | 2004-11-01 |
PublicationDateYYYYMMDD | 2004-11-01 |
PublicationDate_xml | – month: 11 year: 2004 text: 2004-11-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Oxford |
PublicationPlace_xml | – name: Oxford – name: England |
PublicationTitle | Human reproduction (Oxford) |
PublicationTitleAbbrev | Hum. Reprod |
PublicationTitleAlternate | Hum. Reprod |
PublicationYear | 2004 |
Publisher | Oxford University Press Oxford Publishing Limited (England) |
Publisher_xml | – name: Oxford University Press – name: Oxford Publishing Limited (England) |
References | key 20171011124007_R12 key 20171011124007_R13 key 20171011124007_R14 key 20171011124007_R15 key 20171011124007_R30 key 20171011124007_R10 key 20171011124007_R11 key 20171011124007_R27 key 20171011124007_R28 key 20171011124007_R29 key 20171011124007_R7 key 20171011124007_R8 key 20171011124007_R9 key 20171011124007_R3 key 20171011124007_R4 key 20171011124007_R5 key 20171011124007_R6 key 20171011124007_R23 key 20171011124007_R24 key 20171011124007_R1 key 20171011124007_R25 key 20171011124007_R2 key 20171011124007_R26 key 20171011124007_R20 key 20171011124007_R21 key 20171011124007_R22 key 20171011124007_R16 key 20171011124007_R17 key 20171011124007_R18 key 20171011124007_R19 |
References_xml | – ident: key 20171011124007_R23 doi: 10.1111/j.1399-0039.2004.00170.x – ident: key 20171011124007_R5 doi: 10.1016/S0165-0378(02)00059-1 – ident: key 20171011124007_R29 doi: 10.1002/1521-4141(200201)32:1<18::AID-IMMU18>3.0.CO;2-7 – ident: key 20171011124007_R24 doi: 10.1016/S1074-7613(00)80394-5 – ident: key 20171011124007_R13 doi: 10.1002/1521-4141(200006)30:6<1623::AID-IMMU1623>3.0.CO;2-M – ident: key 20171011124007_R10 doi: 10.1016/S0161-5890(97)00032-1 – ident: key 20171011124007_R8 doi: 10.4049/jimmunol.171.4.1768 – ident: key 20171011124007_R30 doi: 10.1111/j.1600-0897.1999.tb00447.x – ident: key 20171011124007_R17 doi: 10.1073/pnas.96.10.5674 – ident: key 20171011124007_R7 doi: 10.1002/eji.200323741 – ident: key 20171011124007_R19 doi: 10.1084/jem.189.7.1093 – ident: key 20171011124007_R14 doi: 10.1053/plac.1999.0496 – ident: key 20171011124007_R22 – ident: key 20171011124007_R4 doi: 10.1016/S0165-0378(03)00046-9 – ident: key 20171011124007_R9 doi: 10.1095/biolreprod56.1.169 – ident: key 20171011124007_R16 doi: 10.1016/S0165-0378(01)00111-5 – ident: key 20171011124007_R26 doi: 10.1034/j.1600-0897.2003.00018.x – ident: key 20171011124007_R1 doi: 10.1093/molehr/7.12.1167 – ident: key 20171011124007_R15 doi: 10.1210/jc.86.4.1823 – ident: key 20171011124007_R27 doi: 10.1002/eji.1830270426 – ident: key 20171011124007_R21 doi: 10.1111/j.1469-1809.1995.tb01608.x – ident: key 20171011124007_R20 doi: 10.4049/jimmunol.167.4.1877 – ident: key 20171011124007_R6 doi: 10.1034/j.1399-0039.2002.590302.x – ident: key 20171011124007_R25 – ident: key 20171011124007_R28 doi: 10.1034/j.1399-0039.2000.560307.x – ident: key 20171011124007_R11 doi: 10.1007/s004410050713 – ident: key 20171011124007_R12 doi: 10.4049/jimmunol.171.7.3415 – ident: key 20171011124007_R18 doi: 10.1111/j.1600-0897.1999.tb00462.x – ident: key 20171011124007_R2 doi: 10.1084/jem.192.2.259 – ident: key 20171011124007_R3 doi: 10.1016/S0165-0378(97)00073-9 |
SSID | ssj0016186 |
Score | 2.0440407 |
Snippet | BACKGROUND: In view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK)... In view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells... BACKGROUNDIn view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK)... |
SourceID | proquest crossref pubmed pascalfrancis oup istex |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 2653 |
SubjectTerms | Abortion, Habitual - genetics Adolescent Adult Biological and medical sciences Case-Control Studies Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Predisposition to Disease Humans killer cell immunoglobulin-like receptors Middle Aged NK cell Pregnancy Receptors, Immunologic - blood Receptors, Immunologic - genetics Receptors, KIR Receptors, KIR2DL1 Receptors, KIR2DL4 recurrent spontaneous abortion |
Title | Maternal KIR repertoire is not associated with recurrent spontaneous abortion |
URI | https://api.istex.fr/ark:/67375/HXZ-5BRRMSGK-Z/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/15333596 https://www.proquest.com/docview/211852841/abstract/ https://search.proquest.com/docview/66993087 |
Volume | 19 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELbKJiEkhKDjRxkMI6G-sHRNYrvJ49igZSMIdZ2o9hI5iaNNqM3UphLlf-B_5pxLnEzqxOAlShPHSv19Od-d786EvIsTrhhTts7G0cuMHrc8xmMrVfZA-V4EOoj2QwZfxeicnUz5tNX63YhaWuVRL_61Ma_kf1CFa4CrzpL9B2RNp3ABzgFfOALCcLwTxoHEEs7vTz-PtfdfLfIMRJjepHye6S1kcOirCPOF9q0X1Zh0XCxohUrHv2oWGHRKNRVd-7rgZVEPFiniYXJhw3fwvVxaOuqd9UwgT5bVO7af1JcBPpgwrWP15WpWKKxBb2juHsuSOmU_lRuClfl4xmjdnN7YkGaOAHPVxsrrPYXSlom-5bhYedaIY79JO7spXAXWFS4navg52DgJYIGsy9UMhglOEnXJPLee70wU4q1t75FtZ-BzbcsPpyZiqNhaAF12-E_Kkq3QxQF2cICP31BxtvXX-rNKn3x4LZfw7aW4acrtVk2h3Uwek0elWUIPkWNPSEvN22TncC7zbLamXVoEChcrMG1yPyjjMdqk-w0rn6_36aRO5FvuF0-YmujrHRJUVKVAVVpTlV4tKVCV1lSlmqrUUJU2qEorqj4l558-To5GVrmThxWDgp5bknux9HmkWJqIREptxAvOwbKTInL7ke2kMHP4sYrTxPGS1GFR5DM38XkScccV7jOyNc_m6gWhnuxLG2QI2BkgZFxPulLwuJ9CUydikeqQbjX44TUWbAkx0MINEaUQUYKGBTSmlVz80FGOAx6Ophch_zAeB2fD0_CiQ94Cdn_rbO8GsnVrARMmZ9Bgt4I6LCXIMnRsXbrAY3aHvDF3QbzrNTsc2FAIMCD63qBDniM_6p7BUHO5L17e4fV2yYP6m31FtvLFSr0GZTqP9gqK_wFj98x2 |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Maternal+KIR+repertoire+is+not+associated+with+recurrent+spontaneous+abortion&rft.jtitle=Human+reproduction+%28Oxford%29&rft.au=Witt%2C+C.S.&rft.au=Goodridge%2C+J.&rft.au=Gerbase-DeLima%2C+M.G.&rft.au=Daher%2C+S.&rft.date=2004-11-01&rft.pub=Oxford+University+Press&rft.issn=0268-1161&rft.eissn=1460-2350&rft.volume=19&rft.issue=11&rft.spage=2653&rft.epage=2657&rft_id=info:doi/10.1093%2Fhumrep%2Fdeh483&rft.externalDocID=10.1093%2Fhumrep%2Fdeh483 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0268-1161&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0268-1161&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0268-1161&client=summon |