Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population

• Published in: Journal of neuroimmunology Vol. 282; pp. 80 - 84
• Main Authors: Čierny, Daniel, Hányšová, Sandra, Michalik, Jozef, Kantorová, Ema, Kurča, Egon, Škereňová, Mária, Lehotský, Ján
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.05.2015
• Subjects: Adult; Allergy and Immunology; Disability progression; Disabled Persons; Disease Progression; Female; Gene Frequency; Gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genotype; Humans; IL7 receptor alpha gene; Interleukin-7 Receptor alpha Subunit - genetics; Male; Middle Aged; MSSS; Multiple sclerosis; Multiple Sclerosis - genetics; Multiple Sclerosis - physiopathology; Neurology; Polymorphism, Single Nucleotide - genetics; rs6897932; Slovakia; Slovakia; Multiple sclerosis; MSSS; Disability progression; rs6897932; IL7 receptor alpha gene; Gene polymorphism
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2015.03.010

Abstract In this study, we determined the association between rs6897932 in interleukin 7 receptor α ( IL7Ra ) gene and the risk and disability progression of multiple sclerosis (MS) in 270 MS patients and 303 controls. We found allele C to be associated with the risk of MS and minor allele T to be protective against MS development. Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores. The minor allele T and genotype TT are protective against a rapid disability progression in MS in the Central European Slovak population.