Factors associated with the drug-resistant tuberculosis incidence rate in Brazil
SETTING: The selection and transmission of drug-resistant strains of tuberculosis (TB) hamper disease control.OBJECTIVE: To identify health conditions, demographic and socio-economic factors, as well as individual factors associated with the incidence of drug-resistant TB (DR-TB), in Brazil at the m...
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Published in | The international journal of tuberculosis and lung disease Vol. 22; no. 6; pp. 675 - 680 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
France
International Union Against Tuberculosis and Lung Disease
01.06.2018
International Union against Tuberculosis and Lung Disease (IUATLD) |
Subjects | |
Online Access | Get full text |
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Summary: | SETTING: The selection and transmission of drug-resistant strains of tuberculosis (TB) hamper disease control.OBJECTIVE: To identify health conditions, demographic and socio-economic factors, as well as individual factors associated with the incidence of drug-resistant TB (DR-TB),
in Brazil at the municipal level.DESIGN: This was an ecological study covering Brazilian municipalities that had reported DR-TB cases in 2014. Associations were evaluated in a multilevel analysis using negative binomial regression.RESULTS: In the multilevel model, males (incidence
rate ratio [IRR] 2.6, 95% confidence interval [CI] 2.3-2.93) and Black persons (IRR 1.82, 95%CI 1.61-2.05) had a higher risk of DR-TB. Compared with those aged 60 years, persons aged 15-59 years (IRR 1.72, 95%CI 1.40-2.11) also had a higher risk. The following
contextual factors were associated with the incidence rate (IR) of DR-TB: proportion of previously treated patients (IRR 1.27, 95%CI 1.1-1.5), acquired immune-deficiency syndrome IR (IRR 1.13, 95%CI 1.02-1.25), Municipal Human Development Index (IRR 0.72, 95%CI 0.64-0.81)
and the Gini coefficient (IRR 0.86, 95%CI 0.78-0.95).CONCLUSION: We have identified individual and contextual factors associated with the incidence of DR-TB. Our results may help improve integrated public health interventions aimed at controlling DR-TB in Brazil. |
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Bibliography: | (R) Medicine - General 1027-3719(20180601)22:6L.675;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1027-3719 1815-7920 |
DOI: | 10.5588/ijtld.17.0667 |