Highly fluorescent sub 40-nm aminated mesoporous silica nanoparticles

We report the room temperature synthesis of highly fluorescent, sub-40 nm aminated mesoporous silica nanoparticles in water using triethanolamine (TEA) as catalyst. Co-condensation reactions between silica precursors, i.e., tetraethoxysilane and 3-aminopropyl triethoxysilane, allows the incorporatio...

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Published inJournal of sol-gel science and technology Vol. 74; no. 1; pp. 32 - 38
Main Authors Suteewong, Teeraporn, Ma, Kai, Drews, Jennifer E., Werner-Zwanziger, Ulrike, Zwanziger, Josef, Wiesner, Ulrich, Bradbury, Michelle S.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.04.2015
Springer Nature B.V
Subjects
Ceramics
Chemistry and Materials Science
Composites
Correlation analysis
Drug delivery systems
Dynamical systems
Dynamics
Fluorescent dyes
Fluorescent indicators
Glass
Inorganic Chemistry
Light scattering
Materials Science
Nanomaterials
Nanoparticles
Nanotechnology
Natural Materials
NMR spectroscopy
Optical and Electronic Materials
Original Paper
Photon correlation spectroscopy
Porosity
Silicon dioxide
Sorption
Spectroscopy
Spectrum analysis
Tetraethyl orthosilicate
Thermogravimetric analysis
Transmission electron microscopy
Triethanolamine
Zeta potential
Amination
Fluorescent
Mesoporous silica
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Summary:We report the room temperature synthesis of highly fluorescent, sub-40 nm aminated mesoporous silica nanoparticles in water using triethanolamine (TEA) as catalyst. Co-condensation reactions between silica precursors, i.e., tetraethoxysilane and 3-aminopropyl triethoxysilane, allows the incorporation of amino moieties and conjugated fluorescent dye (tetramethylrhodamine-5(6)-isothiocyanate; TRITC) throughout the silica matrix. Resulting materials are characterized using a combination of transmission electron microscopy, nitrogen sorption measurements, dynamic light scattering, zeta potential measurements, thermogravimetric analysis, fluorescence correlation spectroscopy and solid-state 29 Si-NMR spectroscopy. The TEA-catalyzed system leads to the formation of bright and discrete sub-40 nm aminated mesoporous silica nanoparticles with disordered pore structure and high organic content. Resulting nanomaterials may find use as simultaneous fluorescent probes and drug delivery vehicles in future theranostic applications.
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ISSN:0928-0707
1573-4846
DOI:10.1007/s10971-014-3567-2