Family History of Gastric Cancer and Helicobacter pylori Treatment

• Published in: The New England journal of medicine Vol. 382; no. 5; pp. 427 - 436
• Main Authors: Choi, Il Ju, Kim, Chan Gyoo, Lee, Jong Yeul, Kim, Young-Il, Kook, Myeong-Cherl, Park, Boram, Joo, Jungnam
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 30.01.2020
• Subjects: Adenoma - epidemiology; Adenoma - etiology; Adenoma - prevention & control; Adult; Aged; Amoxicillin; Amoxicillin - therapeutic use; Anti-Bacterial Agents - therapeutic use; Antibiotics; Biopsy; Clarithromycin; Clarithromycin - therapeutic use; Classification; Disease; Double-Blind Method; Drug Therapy, Combination; Endoscopy; Family medical history; Female; Gastric cancer; Health risk assessment; Helicobacter Infections - complications; Helicobacter Infections - drug therapy; Helicobacter pylori; Humans; Incidence; Infections; Kaplan-Meier Estimate; Lansoprazole - therapeutic use; Male; Middle Aged; Penicillin; Persistent infection; Population; Proton Pump Inhibitors - therapeutic use; Republic of Korea; Risk factors; Stomach Neoplasms - epidemiology; Stomach Neoplasms - etiology; Stomach Neoplasms - genetics; Stomach Neoplasms - prevention & control; Surveillance; Tumors; Ulcers; Republic of Korea; South Korea
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa1909666

Among 1676 persons with H. pylori infection who had family members with gastric cancer, the incidence of gastric cancer over a median follow-up of 9.2 years was significantly lower among those who received eradication treatment for H. pylori infection than among those who received placebo.