Integrated Transcriptomic Analysis Reveals the Molecular Mechanism of Meningiomas by Weighted Gene Coexpression Network Analysis

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 12
• Main Authors: Chu, Sheng-Hua, Ma, Yan-Bin, Wei, Shuxun, Yang, Biao
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analysis; Annotations; Biomarkers; Brain cancer; Computational Biology - methods; Correlation analysis; Databases, Genetic; Datasets; Gene expression; Gene Expression Profiling - methods; Genes; Genetic aspects; Genomes; Humans; Meningeal Neoplasms - genetics; Meningeal Neoplasms - metabolism; Meningioma; Meningioma - genetics; Meningioma - metabolism; Modules; Network analysis; Pathogenesis; Preservation; Prognosis; Protein Interaction Maps - genetics; Transcriptome - genetics; Tumors
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2020/4927547

Meningiomas are the most common primary intracranial tumor in adults. However, to date, systemic coexpression analyses for meningiomas fail to explain its pathogenesis. The aim of the present study was to construct coexpression modules and identify potential biomarkers associated with meningioma progression. Weighted gene coexpression network analysis (WGCNA) was performed based on GSE43290, and module preservation was tested by GSE74385. Functional annotations were performed to analyze biological significance. Hub genes were selected for efficacy evaluations and correlation analyses using two independent cohorts. A total of 14 coexpression modules were identified, and module lightcyan was significantly associated with WHO grades. Functional enrichment analyses of module lightcyan were associated with tumor pathogenesis. The top 10 hub genes were extracted. Ten biomarkers, particularly AHCYL2, FGL2, and KCNMA1, were significantly related to grades and prognosis of meningioma. These findings not only construct coexpression modules leading to the better understanding of its pathogenesis but also provide potential biomarkers that represent specific on tumor grades and identify recurrence, predicting prognosis and progression of meningiomas.