P2X7 Receptor and Extracellular Vesicle Release

• Published in: International journal of molecular sciences Vol. 24; no. 12; p. 9805
• Main Authors: Golia, Maria Teresa, Gabrielli, Martina, Verderio, Claudia
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 06.06.2023; MDPI
• Subjects: Apoptosis; Biosynthesis; Cytokines; Dendritic cells; Extracellular vesicles; inflammation; Kinases; MicroRNAs; Nervous system; neurodegeneration; P2X7 receptor; Plasma; Protein folding; Proteins; Review; Traumatic brain injury

Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion...