P2X7 Receptor and Extracellular Vesicle Release

Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 24; no. 12; p. 9805
Main Authors Golia, Maria Teresa, Gabrielli, Martina, Verderio, Claudia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 06.06.2023
MDPI
Subjects
Apoptosis
Biosynthesis
Cytokines
Dendritic cells
Extracellular vesicles
inflammation
Kinases
MicroRNAs
Nervous system
neurodegeneration
P2X7 receptor
Plasma
Protein folding
Proteins
Review
Traumatic brain injury
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Summary:Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X7R activation on extracellular vesicle release and their activities.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24129805