Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy

• Published in: Acta biomaterialia Vol. 121; pp. 541 - 553
• Main Authors: Liu, Yang, Jin, Jianqiu, Xu, Hao, Wang, Chao, Yang, Yanping, Zhao, Yongjian, Han, Haihui, Hou, Tong, Yang, Guoliang, Zhang, Li, Wang, Yongjun, Zhang, Weian, Liang, Qianqian
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2021; Elsevier BV
• Subjects: Animals; Apoptosis; Arthritis; Arthritis, Rheumatoid - drug therapy; Autoimmune diseases; Biocompatibility; Block copolymers; Cartilage; Collagen; Cytotoxicity; Diterpenes; Epoxy Compounds; Hydrogen-Ion Concentration; Hyperplasia; Inflammation; Intravenous administration; Mice; Nanomedicine; Nanotechnology; pH effects; Pharmacodynamics; Pharmacokinetics; Pharmacology; Phenanthrenes - pharmacology; POSS-PCL-b-PDMAEMA; Rheumatoid arthritis; Toxicity; Triptolide; Rheumatoid arthritis; Triptolide; POSS-PCL-b-PDMAEMA

Rheumatoid arthritis (RA) is a chronicautoimmune disease, marked by joint swelling and pain, articular synovial hyperplasia, as well as cartilage and bone destruction. Triptolide (TP) is an anti-inflammatory molecule but its use to treat RA is limited due to poor solubility and extremely high toxici...