Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice

Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor deve...

Full description

Saved in:
Bibliographic Details
Published inCarcinogenesis (New York) Vol. 15; no. 2; p. 159
Main Authors Fu, P P, Dooley, K L, Von Tungeln, L S, Bucci, T, Hart, R W, Kadlubar, F F
Format Journal Article
LanguageEnglish
Published England 01.02.1994
Subjects
Adenoma - chemically induced
Adenoma - prevention & control
Animals
Biotransformation
Carcinogens - pharmacokinetics
Chrysenes - pharmacokinetics
DNA Damage
Energy Intake
Food Deprivation
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - prevention & control
Male
Mice
Online AccessGet more information

Cover

More Information
Summary:Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/15.2.159